Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · breast-umap@18

SRR8613741

— · F

f6e4c504-c28c-53c8-9f35-9d9d752efdf7

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
—
cancer_type_detailed
—
subtype
F
subtype
F

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • CHOLESTEROL_HOMEOSTASIS+0.390
  • BILE_ACID_METABOLISM+0.350
  • XENOBIOTIC_METABOLISM+0.330
  • ESTROGEN_RESPONSE_EARLY+0.300
  • ANDROGEN_RESPONSE+0.290
  • FATTY_ACID_METABOLISM+0.290
  • NOTCH_SIGNALING+0.260
  • GLYCOLYSIS+0.240
  • PANCREAS_BETA_CELLS+0.240
  • ADIPOGENESIS+0.230

Top 10 suppressed

  • INTERFERON_GAMMA_RESPONSE-0.600
  • ALLOGRAFT_REJECTION-0.590
  • INTERFERON_ALPHA_RESPONSE-0.590
  • E2F_TARGETS-0.510
  • MYC_TARGETS_V1-0.470
  • G2M_CHECKPOINT-0.460
  • IL6_JAK_STAT3_SIGNALING-0.420
  • COMPLEMENT-0.390
  • INFLAMMATORY_RESPONSE-0.390
  • KRAS_SIGNALING_UP-0.290

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR8613710
breast-umap@18
—F0.865
2SRR8518125
breast-umap@18
—F0.839
3SRR8518241
breast-umap@18
—F0.832
4SRR8518290
breast-umap@18
—F0.826
5TCGA-E2-A15E-01A-11R-A12D-07
breast-umap@18
—A0.813
6MNG965
mng-umap@100
——0.811
7GSM6454744
breast-umap@18
—A0.807
8TCGA-S3-AA14-01A-11R-A41B-07
breast-umap@18
—A0.804
9MNG1264
mng-umap@100
——0.802
10TCGA-CV-6935-01A-11R-1915-07
head-neck@1
——0.801

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 26 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
CHOLESTEROL_HOMEOSTASIS0.390Remibrutinib— uncovered
BILE_ACID_METABOLISM0.350Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.330Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.300Inavolisib— uncovered
ANDROGEN_RESPONSE0.290Inavolisib— uncovered
FATTY_ACID_METABOLISM0.290Inavolisib— uncovered
NOTCH_SIGNALING0.260Inavolisib— uncovered
GLYCOLYSIS0.240Inavolisib— uncovered
PANCREAS_BETA_CELLS0.240Cobimetinib— uncovered
ADIPOGENESIS0.230Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.210Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.200Idelalisib— uncovered
MYOGENESIS0.200Inavolisib— uncovered
HEDGEHOG_SIGNALING0.190Inavolisib— uncovered
P53_PATHWAY0.190Idelalisib— uncovered
PEROXISOME0.190Idelalisib— uncovered
APICAL_JUNCTION0.170Inavolisib— uncovered
APICAL_SURFACE0.120Temsirolimus— uncovered
HYPOXIA0.090Idelalisib— uncovered
UV_RESPONSE_UP0.090Idelalisib— uncovered