SRR1367943
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- SPERMATOGENESIS+0.380
- OXIDATIVE_PHOSPHORYLATION+0.373
- PANCREAS_BETA_CELLS+0.372
- KRAS_SIGNALING_DN+0.306
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.190
- UV_RESPONSE_DN+0.000
- PI3K_AKT_MTOR_SIGNALING-0.009
- HEME_METABOLISM-0.020
- APICAL_SURFACE-0.023
- HEDGEHOG_SIGNALING-0.023
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.624
- IL6_JAK_STAT3_SIGNALING-0.546
- INTERFERON_GAMMA_RESPONSE-0.546
- WNT_BETA_CATENIN_SIGNALING-0.474
- NOTCH_SIGNALING-0.420
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.417
- ANGIOGENESIS-0.405
- TNFA_SIGNALING_VIA_NFKB-0.398
- INFLAMMATORY_RESPONSE-0.379
- TGF_BETA_SIGNALING-0.356
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1354446 | GTEX | — | 0.978 |
| 2 | SRR1349056 | GTEX | — | 0.976 |
| 3 | SRR595926 | GTEX | — | 0.973 |
| 4 | SRR1474553 | GTEX | — | 0.971 |
| 5 | SRR1360563 | GTEX | — | 0.971 |
| 6 | SRR1084842 | GTEX | — | 0.962 |
| 7 | SRR1459718 | GTEX | — | 0.961 |
| 8 | SRR660626 | GTEX | — | 0.960 |
| 9 | SRR1389979 | GTEX | — | 0.959 |
| 10 | SRR1481216 | GTEX | — | 0.959 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 5 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| SPERMATOGENESIS | 0.380 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.373 | Remibrutinib | — uncovered |
| PANCREAS_BETA_CELLS | 0.372 | Cobimetinib | — uncovered |
| KRAS_SIGNALING_DN | 0.306 | Remibrutinib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.190 | Inavolisib | — uncovered |