Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-EW-A1PG-01A-11R-A144-07

· A

f9682445-6e0d-51da-9c77-95a183e90b55

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
A
subtype
A
overall_survival_months
35

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1299613f5-2f9a-4687-ab0c-323bf38f3699
melanoma-umap@29
0.899
2TCGA-BH-A201-01A-11R-A14M-07
breast-umap@18
A0.868
3C3L-01838
lung-landscapes@6
cohortSQ10.858
4TCGA-AN-A0AS-01A-11R-A00Z-07
breast-umap@18
C0.857
5ULC1700T_S19
lung-landscapes@6
cohortMD20.852
6TCGA-34-5928-01A-11R-1820-07
lung-landscapes@6
cohortSQ10.842
7TCGA-77-8130-01A-11R-2247-07
lung-landscapes@6
cohortSQ10.810
8TCGA-BH-A0BO-01A-23R-A12D-07
breast-umap@18
A0.807
9TCGA-A2-A259-01A-11R-A16F-07
breast-umap@18
A0.798
10TCGA-77-A5G1-01A-11R-A27Q-07
lung-landscapes@6
cohortSQ10.798

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 33 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
TNFA_SIGNALING_VIA_NFKB0.600Inavolisib— uncovered
ANGIOGENESIS0.580Remibrutinib— uncovered
TGF_BETA_SIGNALING0.570Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.550Inavolisib— uncovered
ANDROGEN_RESPONSE0.490Inavolisib— uncovered
UV_RESPONSE_DN0.480Inavolisib— uncovered
HEDGEHOG_SIGNALING0.380Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.360Idelalisib— uncovered
KRAS_SIGNALING_UP0.350Inavolisib— uncovered
MYC_TARGETS_V20.350Idelalisib— uncovered
NOTCH_SIGNALING0.350Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.350Inavolisib— uncovered
HYPOXIA0.340Idelalisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.330Idelalisib— uncovered
IL2_STAT5_SIGNALING0.310Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.300Inavolisib— uncovered
MYC_TARGETS_V10.300Inavolisib— uncovered
PROTEIN_SECRETION0.300Remibrutinib— uncovered
APICAL_JUNCTION0.290Inavolisib— uncovered
P53_PATHWAY0.280Idelalisib— uncovered