Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

MNG117

fabc9c44-fa5d-5fcc-906f-5136556241ac

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1MNG438
mng-umap@100
0.870
2MNG356
mng-umap@100
0.833
3TCGA-78-7540-01A-11R-2066-07
lung-landscapes@6
cohortA10.832
4MNG795
mng-umap@100
0.812
5MNG10
mng-umap@100
0.805
6SRR1516071
bladder-landscape@3
0.797
7TCGA-55-7284-01B-11R-2241-07
lung-landscapes@6
cohortA10.789
8TCGA-78-7162-01A-21R-2066-07
lung-landscapes@6
cohortA20.787
980ff3d8c-da3f-4a1f-822c-c6132e2b0574
colon-landscapes@1
0.779
10ERR2208890
melanoma-umap@29
0.766

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 32 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
APICAL_SURFACE0.429Temsirolimus— uncovered
TGF_BETA_SIGNALING0.380Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.266Inavolisib— uncovered
APICAL_JUNCTION0.217Inavolisib— uncovered
COAGULATION0.213Binimetinib— uncovered
P53_PATHWAY0.212Idelalisib— uncovered
HEME_METABOLISM0.211Temsirolimus— uncovered
ESTROGEN_RESPONSE_LATE0.193Idelalisib— uncovered
PROTEIN_SECRETION0.180Remibrutinib— uncovered
COMPLEMENT0.174Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.172Inavolisib— uncovered
UV_RESPONSE_DN0.151Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.140Inavolisib— uncovered
KRAS_SIGNALING_DN0.138Remibrutinib— uncovered
BILE_ACID_METABOLISM0.130Inavolisib— uncovered
APOPTOSIS0.117Idelalisib— uncovered
HYPOXIA0.114Idelalisib— uncovered
PEROXISOME0.101Idelalisib— uncovered
INFLAMMATORY_RESPONSE0.093Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.090Inavolisib— uncovered