2c76906f-57a5-42b2-aa73-544814ea4657
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
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- cancer_type_detailed
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- subtype
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GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- G2M_CHECKPOINT+0.300
- HEDGEHOG_SIGNALING+0.300
- SPERMATOGENESIS+0.300
- E2F_TARGETS+0.200
- MITOTIC_SPINDLE+0.200
- PANCREAS_BETA_CELLS+0.200
- WNT_BETA_CATENIN_SIGNALING+0.100
- ANDROGEN_RESPONSE+0.000
- DNA_REPAIR+0.000
- KRAS_SIGNALING_DN+0.000
Top 10 suppressed
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.500
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.400
- IL2_STAT5_SIGNALING-0.400
- TNFA_SIGNALING_VIA_NFKB-0.400
- ADIPOGENESIS-0.300
- ALLOGRAFT_REJECTION-0.300
- ANGIOGENESIS-0.300
- APOPTOSIS-0.300
- CHOLESTEROL_HOMEOSTASIS-0.300
- COAGULATION-0.300
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
6 twins match this tumor's tissue · 4 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | BS_QRDT19KS | medulloblastoma | — | 0.878 |
| 2 | TCGA-56-8083-01A-11R-2247-07 | — | cohortMD1 | 0.872 |
| 3 | BS_A14Z8BBK | medulloblastoma | — | 0.871 |
| 4 | BS_FEV5A0HN | high-grade glioma | — | 0.868 |
| 5 | TCGA-CV-A45U-01A-12R-A24H-07 | — | — | 0.866 |
| 6 | SRR10899974 | — | — | 0.866 |
| 7 | SRR975552 | — | — | 0.865 |
| 8 | X3bde0089.a1cb.45b8.879b.4408eaa25707 | — | cohortMD1 | 0.863 |
| 9 | BS_1TWCV047 | Embryonal tumors | — | 0.861 |
| 10 | C3L-02616 | — | cohortMD1 | 0.860 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 7 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| G2M_CHECKPOINT | 0.300 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.300 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.300 | Inavolisib | — uncovered |
| E2F_TARGETS | 0.200 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.200 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.200 | Cobimetinib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.100 | Inavolisib | — uncovered |