Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
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SRR1404969

GTEX

fb2e08d1-6d96-5f7c-a9f9-762d45874858

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
GTEX
cancer_type_detailed
subtype
cancer_type
GTEX
sex
Female

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • KRAS_SIGNALING_DN+0.272
  • DNA_REPAIR+0.093
  • SPERMATOGENESIS+0.060
  • MYC_TARGETS_V2+0.010
  • PEROXISOME-0.031
  • MYOGENESIS-0.059
  • PANCREAS_BETA_CELLS-0.093
  • APICAL_JUNCTION-0.104
  • MITOTIC_SPINDLE-0.110
  • MYC_TARGETS_V1-0.130

Top 10 suppressed

  • INTERFERON_ALPHA_RESPONSE-0.624
  • TNFA_SIGNALING_VIA_NFKB-0.598
  • INFLAMMATORY_RESPONSE-0.546
  • INTERFERON_GAMMA_RESPONSE-0.527
  • APOPTOSIS-0.512
  • IL6_JAK_STAT3_SIGNALING-0.498
  • TGF_BETA_SIGNALING-0.487
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.481
  • ALLOGRAFT_REJECTION-0.451
  • NOTCH_SIGNALING-0.448

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR1474754
brain-umap@2
GTEX0.990
2SRR1341605
brain-umap@2
GTEX0.987
3SRR1456514
brain-umap@2
GTEX0.987
4SRR1338669
brain-umap@2
GTEX0.984
5SRR1459033
brain-umap@2
GTEX0.983
6SRR1441200
brain-umap@2
GTEX0.983
7SRR1419675
brain-umap@2
GTEX0.981
8SRR1348770
brain-umap@2
GTEX0.981
9SRR1377984
brain-umap@2
GTEX0.980
10SRR1400375
brain-umap@2
GTEX0.978

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 4 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
KRAS_SIGNALING_DN0.272Remibrutinib— uncovered
DNA_REPAIR0.093Idelalisib— uncovered
SPERMATOGENESIS0.060Inavolisib— uncovered
MYC_TARGETS_V20.010Idelalisib— uncovered