C3L-00094

— · cohortA3

fbe036ae-02ee-55d3-b9cf-b5f12be74caf

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type: —
cancer_type_detailed: —
subtype: cohortA3
subtype: cohortA3
age_years: 69.97946612

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

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Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#	Sample	Cancer type	Subtype	cos similarity
1	TCGA-BH-A204-01A-11R-A157-07 breast-umap@18	—	B	0.860
2	TCGA-E9-A228-01A-31R-A157-07 breast-umap@18	—	B	0.850
3	SRR3147744 colon-landscapes@1	—	—	0.833
4	BS_1HQ76V6D brain-umap@2	Embryonal tumors	—	0.832
5	SRR1797279 lung-landscapes@6	—	cohortSC	0.828
6	SRR8613751 breast-umap@18	—	C	0.827
7	R375 bladder-landscape@3	—	—	0.824
8	TCGA-86-8054-01A-11R-2241-07 lung-landscapes@6	—	cohortA3	0.822
9	R6 bladder-landscape@3	—	—	0.821
10	SJEPD031150_D1.RNA-Seq medullo-epn-umap@date-based	EPN	EPN Tumor	0.821

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 16 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)	tumor score	Best drug	reversal magnitude
E2F_TARGETS	0.330	Inavolisib	— uncovered
G2M_CHECKPOINT	0.320	Inavolisib	— uncovered
MYC_TARGETS_V1	0.280	Inavolisib	— uncovered
UNFOLDED_PROTEIN_RESPONSE	0.200	Idelalisib	— uncovered
ANDROGEN_RESPONSE	0.180	Inavolisib	— uncovered
OXIDATIVE_PHOSPHORYLATION	0.180	Remibrutinib	— uncovered
ANGIOGENESIS	0.170	Remibrutinib	— uncovered
MITOTIC_SPINDLE	0.160	Inavolisib	— uncovered
PI3K_AKT_MTOR_SIGNALING	0.160	Inavolisib	— uncovered
PROTEIN_SECRETION	0.160	Remibrutinib	— uncovered
MTORC1_SIGNALING	0.140	Inavolisib	— uncovered
PANCREAS_BETA_CELLS	0.130	Cobimetinib	— uncovered
SPERMATOGENESIS	0.100	Inavolisib	— uncovered
DNA_REPAIR	0.050	Idelalisib	— uncovered
ESTROGEN_RESPONSE_EARLY	0.050	Inavolisib	— uncovered
WNT_BETA_CATENIN_SIGNALING	0.010	Inavolisib	— uncovered