Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · head-neck@1

TCGA-CQ-7071-01A-12R-A30B-07

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fdcf1c92-1af0-5f00-9dc8-7947f8e12354

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
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cancer_type_detailed
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subtype
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sex
female

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

5 twins match this tumor's tissue · 5 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1MDT-AP-0173
medullo-epn-umap@date-based
MedMedulloblastoma0.851
2MDT-AP-3095
medullo-epn-umap@date-based
MedMedulloblastoma0.847
3SJEPD031285_D1.RNA-Seq
medullo-epn-umap@date-based
EPNEPN Tumor0.845
4MDT-AP-2910
medullo-epn-umap@date-based
MedMedulloblastoma0.844
5BS_WRHDP7WF
medullo-epn-umap@date-based
EPNPosterior Fossa EPN0.838
6TCGA-CN-4734-01A-01R-1436-07
head-neck@1
——0.838
7DRR168605
bladder-landscape@3
——0.821
8SRR10900560
melanoma-umap@29
——0.819
9SRR6013563
lung-landscapes@6
—cohortMD20.819
10C3L-00093
lung-landscapes@6
—cohortA10.819

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 37 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.380Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.360Idelalisib— uncovered
HYPOXIA0.350Idelalisib— uncovered
KRAS_SIGNALING_UP0.350Inavolisib— uncovered
PROTEIN_SECRETION0.350Remibrutinib— uncovered
MYC_TARGETS_V10.330Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.330Inavolisib— uncovered
ALLOGRAFT_REJECTION0.320Idelalisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.320Remibrutinib— uncovered
ANDROGEN_RESPONSE0.280Inavolisib— uncovered
MTORC1_SIGNALING0.280Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.270Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.270Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.270Idelalisib— uncovered
UV_RESPONSE_DN0.270Inavolisib— uncovered
COMPLEMENT0.260Inavolisib— uncovered
P53_PATHWAY0.260Idelalisib— uncovered
APOPTOSIS0.220Idelalisib— uncovered
PANCREAS_BETA_CELLS0.190Cobimetinib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.180Idelalisib— uncovered