SRR1085825
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1310008 | GTEX | — | 0.951 |
| 2 | SRR1440058 | GTEX | — | 0.948 |
| 3 | SRR1373858 | GTEX | — | 0.947 |
| 4 | SRR1320280 | GTEX | — | 0.946 |
| 5 | SRR1323746 | GTEX | — | 0.946 |
| 6 | SRR1399028 | GTEX | — | 0.943 |
| 7 | SRR1453851 | GTEX | — | 0.943 |
| 8 | SRR1350456 | GTEX | — | 0.942 |
| 9 | SRR810877 | GTEX | — | 0.941 |
| 10 | SRR1343841 | GTEX | — | 0.939 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 13 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| OXIDATIVE_PHOSPHORYLATION | 0.378 | Remibrutinib | — uncovered |
| KRAS_SIGNALING_DN | 0.372 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.298 | Inavolisib | — uncovered |
| MYOGENESIS | 0.238 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.202 | Cobimetinib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.179 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.132 | Temsirolimus | — uncovered |
| HEDGEHOG_SIGNALING | 0.129 | Inavolisib | — uncovered |
| UV_RESPONSE_UP | 0.127 | Idelalisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.067 | Idelalisib | — uncovered |
| APICAL_JUNCTION | 0.037 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.017 | Inavolisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.009 | Inavolisib | — uncovered |