0357aa51-9436-4923-9b1e-eb22bdf647df
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- age_years
- 75
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PROTEIN_SECRETION+0.200
- WNT_BETA_CATENIN_SIGNALING+0.120
- UNFOLDED_PROTEIN_RESPONSE+0.110
- SPERMATOGENESIS+0.040
- COAGULATION+0.020
- UV_RESPONSE_DN+0.000
- ANDROGEN_RESPONSE-0.010
- MITOTIC_SPINDLE-0.010
- ANGIOGENESIS-0.030
- BILE_ACID_METABOLISM-0.030
Top 10 suppressed
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.430
- INFLAMMATORY_RESPONSE-0.400
- INTERFERON_GAMMA_RESPONSE-0.390
- MYC_TARGETS_V2-0.370
- TNFA_SIGNALING_VIA_NFKB-0.350
- ALLOGRAFT_REJECTION-0.320
- ADIPOGENESIS-0.290
- MYOGENESIS-0.280
- OXIDATIVE_PHOSPHORYLATION-0.280
- UV_RESPONSE_UP-0.270
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MDT-AP-2885 | Med | Medulloblastoma | 0.873 |
| 2 | TCGA-GU-A42R-01A-11R-A23N-07 | — | — | 0.862 |
| 3 | SRR8752376 | — | — | 0.858 |
| 4 | MDT-AP-3246 | Med | Medulloblastoma | 0.850 |
| 5 | SRR650132 | — | — | 0.849 |
| 6 | TCGA-A7-A0DC-01A-11R-A00Z-07 | — | D | 0.848 |
| 7 | TCGA-A7-A13G-01A-11R-A13Q-07 | — | D | 0.847 |
| 8 | ed8896f8-24ef-43a4-ace6-ed9353bd11c2 | — | — | 0.842 |
| 9 | TCGA-A7-A3IZ-01A-11R-A213-07 | — | B | 0.841 |
| 10 | SRR1100872 | GTEX | — | 0.837 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 5 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PROTEIN_SECRETION | 0.200 | Remibrutinib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.120 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.110 | Idelalisib | — uncovered |
| SPERMATOGENESIS | 0.040 | Inavolisib | — uncovered |
| COAGULATION | 0.020 | Binimetinib | — uncovered |