Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

BS_KX6J8TRK

pilocytic astrocytoma

fffd970e-1c3c-5091-9003-902800256c50

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
pilocytic astrocytoma
cancer_type_detailed
subtype
cancer_type
pilocytic astrocytoma
overall_survival_months
167.44415243101182
age_years
2.934
sex
Male

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

4 twins match this tumor's tissue · 6 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1BS_FJZPQZ2C
brain-umap@2
pleomorphic xanthoastrocytoma(PXA)0.927
2SRR5088929
melanoma-umap@29
0.925
3BS_24AHZ9ZW
brain-umap@2
low-grade glioma0.920
4BS_KXH37MPN
brain-umap@2
DNET0.918
5BS_D3YBV7KB
brain-umap@2
low-grade glioma0.915
6BS_Z0AVVB1V
brain-umap@2
pilocytic astrocytoma0.912
7BS_8VAZSJEN
brain-umap@2
pilocytic astrocytoma0.908
8SRR1459211
brain-umap@2
GTEX0.907
974cffe84-dca8-4673-925a-9e0d6344832a
melanoma-umap@29
0.902
10BS_T55Y4Z0Y
brain-umap@2
low-grade glioma0.902

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 37 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_GAMMA_RESPONSE0.636Idelalisib— uncovered
INTERFERON_ALPHA_RESPONSE0.622Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.598Inavolisib— uncovered
ALLOGRAFT_REJECTION0.562Idelalisib— uncovered
INFLAMMATORY_RESPONSE0.561Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.498Inavolisib— uncovered
COMPLEMENT0.471Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.444Inavolisib— uncovered
IL2_STAT5_SIGNALING0.430Idelalisib— uncovered
COAGULATION0.422Binimetinib— uncovered
BILE_ACID_METABOLISM0.393Inavolisib— uncovered
KRAS_SIGNALING_UP0.388Inavolisib— uncovered
APOPTOSIS0.351Idelalisib— uncovered
NOTCH_SIGNALING0.343Inavolisib— uncovered
P53_PATHWAY0.327Idelalisib— uncovered
XENOBIOTIC_METABOLISM0.298Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.290Idelalisib— uncovered
PANCREAS_BETA_CELLS0.287Cobimetinib— uncovered
KRAS_SIGNALING_DN0.282Remibrutinib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.280Inavolisib— uncovered