KIRhub 2.0· v2

Pemigatinib

7bbbb4e8-abff-5e4e-9d06-49590c345b5c · FDA Approved · targets FGFR2

Pemigatinib

MeasuredReference

Pemigatinib targets FGFR1, FGFR3, FGFR2. Strongest hallmark effect: tumor promoting inflammation.

Primary targets

FGFR1 FGFR3 FGFR2 EIF2AK1 CSF1R

Top hallmarks

tumor promoting inflammation2.3k
proliferation1.9k
evading apoptosis1.7k

Top pathways disrupted

pi3k akt mtor signaling5.1k
apical junction4.3k
allograft rejection4.0k

Resistance landscape — Pemigatinib

MeasuredReference

10 known oncogenic variants exist on Pemigatinib's top targets — see detail for inhibition impact.

FGFR1 2 known variants
- FGFR1 (V561M)
- FGFR1 (W666R)
FGFR3 5 known variants
FGFR2 3 known variants

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