Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
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Neratinib

a3ba3ff3-c677-52f4-992a-b4c2790b6e7d · FDA Approved · targets ERBB2_HER2

Neratinib

MeasuredReference

Neratinib targets EGFR, ERBB4_HER4, ERBB2_HER2. Strongest hallmark effect: tumor promoting inflammation.

Top hallmarks

  • tumor promoting inflammation5.9k
  • proliferation5.0k
  • evading apoptosis4.8k

Top pathways disrupted

  • apical junction10.6k
  • allograft rejection10.3k
  • pi3k akt mtor signaling9.8k

Resistance landscape — Neratinib

MeasuredReference

10 known oncogenic variants exist on Neratinib's top targets — see detail for inhibition impact.

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