EGFR
Top inhibitors
| Drug | Inhibition % | Gini |
|---|---|---|
| Neratinib | 100.0 | 0.60 |
| Mobocertinib | 100.0 | 0.76 |
| Lazertinib | 100.0 | 0.67 |
| Afatinib | 100.0 | 0.71 |
| Gefitinib | 99.9 | 0.65 |
| Dacomitinib | 99.8 | 0.66 |
| Erlotinib | 99.4 | 0.69 |
| Ibrutinib | 99.3 | 0.72 |
| Vandetanib | 99.3 | 0.72 |
| Bosutinib | 99.3 | 0.55 |
| Lapatinib | 99.2 | 0.62 |
| Pralsetinib | 99.1 | 0.64 |
| Osimertinib | 99.1 | 0.73 |
| Brigatinib | 98.5 | 0.51 |
| Canertinib | 98.4 | 0.67 |
Known variants
- EGFR (A763_Y764insFHEA)
- EGFR (A763_Y764insFQEA)
- EGFR (A767_S768insTLA)
- EGFR (C775S/T790M/L858R)
- EGFR (C797A)
- EGFR (C797G/L858R)
- EGFR (C797S)
- EGFR (C797S/L858R)
- EGFR (D761Y)
- EGFR (D770GY)
- EGFR (D770_N771insG)
- EGFR (D770_N771insNPG)
- EGFR (D770_N771insNPG/T790M)
- EGFR (G719C)
- EGFR (G719D)
- EGFR (G719S)
- EGFR (K716A)
- EGFR (K716A/C797S/L858R)
- EGFR (K716A/T790M/C797S/L858R)
- EGFR (K716Q/L718Q)
- EGFR (K728A)
- EGFR (K728A/T790M/C797S/L858R)
- EGFR (L718Q)
- EGFR (L747S)
- EGFR (L792F)
- EGFR (L792F/L858R)
- EGFR (L792H)
- EGFR (L792H/C797S/L858R)
- EGFR (L792H/L858R)
- EGFR (L858R)
- EGFR (L861Q)
- EGFR (N771_P772insH)
- EGFR (N771_P772insN)
- EGFR (R999A)
- EGFR (S768I)
- EGFR (T790M)
- EGFR (T790M/C797G/L858R)
- EGFR (T790M/C797S)
- EGFR (T790M/C797S/L858R)
- EGFR (T790M/L792F/C797S/L858R)
- EGFR (T790M/L792F/L858R)
- EGFR (T790M/L792H/C797S/L858R)
- EGFR (T790M/L792H/L858R)
- EGFR (T790M/L858R)
- EGFR (V769_D770insGE)
- EGFR (V948R)
- EGFR (d746)
- EGFR (d746-750)
- EGFR (d746-750/C775S/T790M/L858R)
- EGFR (d746-750/C797A)
- EGFR (d746-750/C797S)
- EGFR (d746-750/G724S)
- EGFR (d746-750/S768I)
- EGFR (d746-750/T790M)
- EGFR (d746-750/T790M/C797S)
- EGFR (d746-750/T790M/C797S/L858R)
- EGFR (d746-750/T790M/L792F)
- EGFR (d746-750/T790M/L792H)
- EGFR (d746-750/T790M/L798I)
- EGFR (d746-750/T790M/L858R)
- EGFR (d747-749)
- EGFR (d747-749/A750P)
- EGFR (d747-752/P753S)
- EGFR (d752-759)
Cancer associations
| Mutation | Cancer type | Organ | Source |
|---|---|---|---|
A750P | carcinoma_lung | Lung | https://doi.org/10.1093/nar/gkaa945 |
A750P | lymphoid_neoplasm_haematopoietic_and_lymphoid_tissue | Blood/Lymphatic System | https://doi.org/10.1093/nar/gkaa945 |
A763 | carcinoma_lung | Lung | https://doi.org/10.1093/nar/gkaa945 |
A767 | carcinoma_lung | Lung | https://doi.org/10.1093/nar/gkaa945 |
A767 | glioma_central_nervous_system | Brain/CNS | https://doi.org/10.1093/nar/gkaa945 |
A767 | carcinoma_liver | Liver | https://doi.org/10.1093/nar/gkaa945 |
A767 | carcinoma_NS | Other | https://doi.org/10.1093/nar/gkaa945 |
A767 | LIHC | Liver | https://doi.org/10.1093/nar/gkaa945 |
A767 | LUAD | Lung | https://doi.org/10.1093/nar/gkaa945 |
C797G | carcinoma_lung | Lung | https://doi.org/10.1093/nar/gkaa945 |
C797A | carcinoma_lung | Lung | https://doi.org/10.1158/2159-8290.CD-12-0095 |
C797S | carcinoma_lung | Lung | https://doi.org/10.1093/nar/gkaa945 |
D761Y | other_lung | Lung | https://doi.org/10.1093/nar/gkaa945 |
D761Y | carcinoma_lung | Lung | https://doi.org/10.1093/nar/gkaa945 |
D770 | carcinoma_lung | Lung | https://doi.org/10.1093/nar/gkaa945 |
D770 | carcinoma_endometrium | Uterus | https://doi.org/10.1093/nar/gkaa945 |
D770 | thymic_carcinoma_thymus | Thyroid | https://doi.org/10.1093/nar/gkaa945 |
D770 | fibrous_hamartoma_of_infancy_soft_tissue | Soft Tissue | https://doi.org/10.1093/nar/gkaa945 |
D770 | carcinoma_urinary_tract | Bladder | https://doi.org/10.1093/nar/gkaa945 |
D770 | glioma_central_nervous_system | Brain/CNS | https://doi.org/10.1093/nar/gkaa945 |