Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
KIRhub 2.0· v2
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Entrectinib

b80dc493-970f-59d6-818b-227832df1283 · FDA Approved · targets TRKA

Entrectinib

MeasuredReference

Entrectinib targets HASPIN, NTRK2, RET.

Primary targets

HASPINNTRK2RETROS_ROS1TXK

Top hallmarks

No hallmark data.

Top pathways disrupted

  • allograft rejection10.3k
  • pi3k akt mtor signaling9.3k
  • apical junction9.1k

Resistance landscape — Entrectinib

MeasuredReference

10 known oncogenic variants exist on Entrectinib's top targets — see detail for inhibition impact.

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