Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
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RET

RBC: RET · Substrate: TRK-C derived peptide ·

Top inhibitors

MeasuredDerived
DrugInhibition %Gini
Nintedanib100.00.61
Pralsetinib100.00.64
Gilteritinib100.00.51
Ponatinib100.00.53
Selpercatinib100.00.64
Fedratinib99.90.58
Tivozanib99.70.67
Alpelisib99.60.72
Entrectinib99.60.67
Lenvatinib98.80.73
Regorafenib98.70.72
Vandetanib98.60.72
Tenalisib98.50.70
Alectinib97.80.65
Futibatinib97.70.72

Known variants

Cancer associations

MutationCancer typeOrganSource
A883Fcarcinoma_thyroidThyroidhttps://doi.org/10.1093/nar/gkaa945
G691Scarcinoma_breastBreasthttps://doi.org/10.1093/nar/gkaa945
G691Shaemangioblastoma_soft_tissueSoft Tissuehttps://doi.org/10.1093/nar/gkaa945
G691Smeningioma_meningesBrain/CNShttps://doi.org/10.1093/nar/gkaa945
G691Scarcinoma_lungLunghttps://doi.org/10.1093/nar/gkaa945
G691Scarcinoma_large_intestineLarge Intestinehttps://doi.org/10.1093/nar/gkaa945
G691Spheochromocytoma_adrenal_glandAdrenalhttps://doi.org/10.1093/nar/gkaa945
G691Shaematopoietic_neoplasm_haematopoietic_and_lymphoid_tissueBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
G691SBRCA-KRBreasthttps://doi.org/10.1093/nar/gkaa945
G691SLAML-KRBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
G691SLUSC-KRBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
G810Ccarcinoma_lungLunghttps://www.cancer.gov/tcga.
G810Ccarcinoma_thyroidThyroidhttps://www.cancer.gov/tcga.
G810Rcarcinoma_lungLunghttps://www.cancer.gov/tcga.
G810Rcarcinoma_thyroidThyroidhttps://doi.org/10.1158/2159-8290.CD-12-0095
G810Scarcinoma_lungLunghttps://doi.org/10.1158/2159-8290.CD-12-0095
G810Scarcinoma_thyroidThyroidhttps://doi.org/10.1158/2159-8290.CD-12-0095
L730Icarcinoma_thyroidThyroidhttps://depmap.org/portal.
M918Tcarcinoma_thyroidThyroidhttps://doi.org/10.1093/nar/gkaa945
M918Tpheochromocytoma_adrenal_glandAdrenalhttps://doi.org/10.1093/nar/gkaa945
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