Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
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AKT1

RBC: AKT1 · Substrate: Crosstide ·

Top inhibitors

MeasuredDerived
DrugInhibition %Gini
Capivasertib97.70.64
Netarsudil47.50.68
Midostaurin19.90.50
Ripretinib15.60.67
Leniolisib13.00.60
Tivozanib12.10.67
Nilotinib11.30.77
Deucravacitinib10.80.72
Umbralisib10.40.67
Vemurafenib10.10.60
Gefitinib9.90.65
Canertinib9.60.67
Cabozantinib9.60.75
Fedratinib9.50.58
Erdafitinib9.40.74

Known variants

Cancer associations

MutationCancer typeOrganSource
E17KBladder CancerBladderhttps://doi.org/10.1093/nar/gkaa945
E17KThyroid CancerThyroidhttps://doi.org/10.1093/nar/gkaa945
E17KBile Duct CancerLiverhttps://doi.org/10.1093/nar/gkaa945
E17Kmeningioma_meningesBrain/CNShttps://doi.org/10.1093/nar/gkaa945
E17KOvergrowth_syndrome_skinSkinhttps://doi.org/10.1093/nar/gkaa945
E17Kcarcinoma_breastBreasthttps://doi.org/10.1093/nar/gkaa945
E17Kcarcinoma_large_intestineLarge Intestinehttps://doi.org/10.1093/nar/gkaa945
E17Kcarcinoma_endometriumUterushttps://doi.org/10.1093/nar/gkaa945
E17Kcarcinoma_NSOtherhttps://doi.org/10.1093/nar/gkaa945
E17KOvergrowth_syndrome_boneBonehttps://doi.org/10.1093/nar/gkaa945
E17Kcarcinoma_salivary_glandSalivary Glandhttps://doi.org/10.1093/nar/gkaa945
E17Kcarcinoma_thyroidThyroidhttps://doi.org/10.1093/nar/gkaa945
E17Kcarcinoma_urinary_tractBladderhttps://doi.org/10.1093/nar/gkaa945
E17Kother_pancreasPancreashttps://doi.org/10.1093/nar/gkaa945
E17Kcarcinoma_ovaryOvaryhttps://doi.org/10.1093/nar/gkaa945
E17Kcarcinoma_upper_aerodigestive_tractStomach/Digestive Tracthttps://doi.org/10.1093/nar/gkaa945
E17Kcarcinoma_prostateProstatehttps://doi.org/10.1093/nar/gkaa945
E17Kother_peritoneumStomach/Digestive Tracthttps://doi.org/10.1093/nar/gkaa945
E17Kcarcinoma_pancreasPancreashttps://doi.org/10.1093/nar/gkaa945
E17Kcarcinoma_lungLunghttps://doi.org/10.1093/nar/gkaa945
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