Ceritinib — dose-response

Dose-response curves across the assayed kinome. ← All drugs

Ceritinib × CIT

IC50

15.13 nM

Hill slope

2.01

R²

0.3142

Top kinases by potency

Ordered by IC50 ascending (fitted).

Kinase	IC50
CSNK2A1	0.26 nM
CDK9+CCNT2	0.28 nM
CDK3+CCNE1	0.30 nM
NEK7	0.32 nM
PLK3	0.56 nM
MAPK12	0.74 nM
ROS1	0.75 nM
ALK	1.69 nM
BMPR2	2.00 nM
CDC7	2.14 nM
RIPK2	2.23 nM
ACVR1B	2.31 nM
WEE1	2.34 nM
MAPKAPK2	2.41 nM
PDPK1	2.43 nM
MAP3K3	2.72 nM
FES	3.21 nM
LRRK2	3.79 nM
BMX	4.10 nM
AKT3	4.22 nM
IGF1R	4.99 nM
PAK3	5.91 nM
MAPKAPK3	7.00 nM
TSSK1B	7.40 nM
CDK2+CCNA2	8.72 nM
TYRO3	10.84 nM
PTK2	11.28 nM
CIT	15.13 nM
TNK1	18.06 nM
IKBKE	18.85 nM