Ponatinib — dose-response

MeasuredDerived

Dose-response curves across the assayed kinome. ← All drugs

Ponatinib × ABL1

MeasuredDerived

IC50

0.93 nM

Hill slope

1.30

R²

1.0000

Top kinases by potency

MeasuredDerived

Ordered by IC50 ascending (fitted).

Kinase	IC50
LYN_2	0.48 nM
ABL2	0.56 nM
LYN	0.62 nM
BLK	0.85 nM
FGR	0.89 nM
ABL1	0.93 nM
LCK	1.33 nM
EPHB2	1.42 nM
EPHA5	1.43 nM
PDGFRA	1.76 nM
YES1	2.05 nM
HCK	2.30 nM
KDR	2.41 nM
TNK1	2.51 nM
RET	2.57 nM
EPHA2	2.69 nM
SRC	2.94 nM
EPHA4	3.30 nM
CSF1R	3.39 nM
EPHB3	3.53 nM
CSK	3.61 nM
EPHB1	3.62 nM
DDR2	3.93 nM
FYN	4.32 nM
EPHA6	4.45 nM
MAP3K20	5.25 nM
EPHB4	5.30 nM
PDGFRB	5.75 nM
FRK	6.02 nM
EPHA8	7.37 nM