Ponatinib — dose-response

Dose-response curves across the assayed kinome. ← All drugs

Ponatinib × HCK

IC50

2.30 nM

Hill slope

1.94

R²

1.0000

Top kinases by potency

Ordered by IC50 ascending (fitted).

Kinase	IC50
LYN_2	0.48 nM
ABL2	0.56 nM
LYN	0.62 nM
BLK	0.85 nM
FGR	0.89 nM
ABL1	0.93 nM
LCK	1.33 nM
EPHB2	1.42 nM
EPHA5	1.43 nM
PDGFRA	1.76 nM
YES1	2.05 nM
HCK	2.30 nM
KDR	2.41 nM
TNK1	2.51 nM
RET	2.57 nM
EPHA2	2.69 nM
SRC	2.94 nM
EPHA4	3.30 nM
CSF1R	3.39 nM
EPHB3	3.53 nM
CSK	3.61 nM
EPHB1	3.62 nM
DDR2	3.93 nM
FYN	4.32 nM
EPHA6	4.45 nM
MAP3K20	5.25 nM
EPHB4	5.30 nM
PDGFRB	5.75 nM
FRK	6.02 nM
EPHA8	7.37 nM