UniProt Q9UM73 · PDB · AlphaFold · Substrate: pEY · Clone: cytoplasmic aa1058-1620
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Gilteritinib | 99.5% | 0.5% | 88.97 | 0.506 |
| 2 | Repotrectinib | 99.4% | 0.6% | 84.21 | 0.608 |
| 3 | Brigatinib | 99.2% | 0.8% | 82.96 | 0.513 |
| 4 | Entrectinib | 98.8% | 1.2% | 93.69 | 0.671 |
| 5 | Alectinib | 98.6% | 1.4% | 95.49 | 0.651 |
| 6 | Ceritinib | 98.3% | 1.7% | 95.44 | 0.618 |
| 7 | Crizotinib | 97.7% | 2.3% | 91.39 | 0.581 |
| 8 | Lorlatinib | 97.2% | 2.8% | 97.24 | 0.694 |
| 9 | Sunitinib | 87.7% | 12.3% | 91.73 | 0.524 |
| 10 | Nintedanib | 84.9% | 15.1% | 90.23 | 0.608 |
| 11 | Pralsetinib | 82.6% | 17.4% | 93.43 | 0.643 |
| 12 | Alpelisib | 80.7% | 19.3% | 97.22 | 0.720 |
| 13 | Osimertinib | 80.5% | 19.5% | 97.24 | 0.733 |
| 14 | Bosutinib | 75.1% | 24.9% | 87.22 | 0.555 |
| 15 | Pacritinib | 55.3% | 44.7% | 88.64 | 0.452 |
| 16 | Ruxolitinib | 52.1% | 47.9% | 98.25 | 0.592 |
| 17 | Baricitinib | 46.4% | 53.6% | 97.99 | 0.616 |
| 18 | Lazertinib | 46.3% | 53.7% | 97.47 | 0.674 |
| 19 | Tenalisib | 45.2% | 54.8% | 97.98 | 0.702 |
| 20 | Midostaurin | 42.4% | 57.6% | 78.64 | 0.500 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 0.35
- Epithelial log2(TPM+1): 0.50
- Fold change: -0.15
- Status: No significant change
Selectivity landscape vs inhibition on ALK
Each point is one of the 92 approved drugs; color = inhibition % on ALK.
Mutation lollipop
Cancer-associated mutations plotted by residue position. Marker size + color scale with the number of distinct cancer reports.
Variants (16)
Mutation × cancer associations
| Mutation | Cancer | Organ | Source |
|---|---|---|---|
| C1156Y | carcinoma_lung | Lung | ref |
| D1203N | carcinoma_lung | Lung | ref |
| F1174L | Neuroblastoma | Brain/CNS | ref |
| F1174L | neuroblastoma_autonomic_ganglia | Brain/CNS | ref |
| F1174L | mesothelioma_pleura | Lung | ref |
| F1174L | carcinoma_kidney | Kidney | ref |
| F1174L | carcinoma_lung | Lung | ref |
| F1174L | neuroblastic_tumour_autonomic_ganglia | Brain/CNS | ref |
| F1174L | carcinoma_skin | Skin | ref |
| F1174L | ganglioneuroblastoma_autonomic_ganglia | Brain/CNS | ref |
| F1174L | inflammatory_myofibroblastic_tumour_soft_tissue | Soft Tissue | ref |
| F1174L | carcinoma_salivary_gland | Salivary Gland | ref |
| F1174L | carcinoma_prostate | Prostate | ref |
| F1174L | NBL-US | Brain/CNS | ref |
| F1174L | NB | Brain/CNS | ref |
| F1174S | neuroblastoma_autonomic_ganglia | Brain/CNS | ref |
| F1174S | carcinoma_endometrium | Uterus | ref |
| G1202R | carcinoma_lung | Lung | ref |
| G1202R | malignant_melanoma_skin | Skin | ref |
| G1269A | carcinoma_lung | Lung | ref |
| G1269A | epithelioid_inflammatory_myofibroblastic_sarcoma_soft_tissue | Soft Tissue | ref |
| G1269S | carcinoma_lung | Lung | |
| G1269S | anaplastic_large_cell_lymphoma | Blood/Lymphatic System | |
| L1152INST | carcinoma_lung | Lung | |
| L1152INST | anaplastic_large_cell_lymphoma | Blood/Lymphatic System | |
| S1206R | carcinoma_lung | Lung | |
| S1206R | anaplastic_large_cell_lymphoma | Blood/Lymphatic System | |
| T1151M | carcinoma_lung | Lung | ref |
| T1151M | anaplastic_large_cell_lymphoma | Blood/Lymphatic System | ref |
| I1171N | carcinoma_lung | Lung | ref |
Showing 30 of 48 associations.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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