UniProt P30530 · PDB · AlphaFold · Substrate: pEY · Clone: aa 473-894 endhigh-confidence target
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Gilteritinib | 98.7% | 1.3% | 88.97 | 0.506 |
| 2 | Crizotinib | 97.1% | 2.9% | 91.39 | 0.581 |
| 3 | Neratinib | 96.3% | 3.7% | 93.18 | 0.597 |
| 4 | Cabozantinib | 95.9% | 4.1% | 92.73 | 0.751 |
| 5 | Sunitinib | 90.6% | 9.4% | 91.73 | 0.524 |
| 6 | Bosutinib | 89.9% | 10.1% | 87.22 | 0.555 |
| 7 | Pacritinib | 89.8% | 10.2% | 88.64 | 0.452 |
| 8 | Brigatinib | 85.3% | 14.7% | 82.96 | 0.513 |
| 9 | Selpercatinib | 85.2% | 14.8% | 96.72 | 0.635 |
| 10 | Lazertinib | 81.1% | 18.9% | 97.47 | 0.674 |
| 11 | Nintedanib | 79.5% | 20.4% | 90.23 | 0.608 |
| 12 | Repotrectinib | 77.8% | 22.2% | 84.21 | 0.608 |
| 13 | Pralsetinib | 76.7% | 23.3% | 93.43 | 0.643 |
| 14 | Fedratinib | 76.3% | 23.7% | 96.21 | 0.576 |
| 15 | Alectinib | 75.8% | 24.2% | 95.49 | 0.651 |
| 16 | Entrectinib | 73.6% | 26.4% | 93.69 | 0.671 |
| 17 | Tivozanib | 72.8% | 27.2% | 92.42 | 0.673 |
| 18 | Defactinib | 69.9% | 30.1% | 92.68 | 0.450 |
| 19 | Tepotinib | 69.6% | 30.4% | 99.75 | 0.727 |
| 20 | Axitinib | 64.9% | 35.1% | 93.23 | 0.688 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 7.00
- Epithelial log2(TPM+1): 1.35
- Fold change: 5.65
- Status: Upregulated
High-confidence drugs
- Cabozantinib — inh 95.9% · KISS 41.07
- Neratinib — inh 96.3% · KISS 37.30
- Crizotinib — inh 97.1% · KISS 35.70
Selectivity landscape vs inhibition on AXL
Each point is one of the 92 approved drugs; color = inhibition % on AXL.
Mutation lollipop
Cancer-associated mutations plotted by residue position. Marker size + color scale with the number of distinct cancer reports.
Variants (1)
Mutation × cancer associations
| Mutation | Cancer | Organ | Source |
|---|---|---|---|
| R499C | carcinoma_skin | Skin | ref |
| R499C | carcinoma_large_intestine | Large Intestine | ref |
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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