PTK6(BRK)
Sign in to save this workspaceUniProt Q13882 · PDB · AlphaFold · Substrate: pEY + Mn · Clone: full-length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Cabozantinib | 99.5% | 0.5% | 92.73 | 0.751 |
| 2 | Vemurafenib | 98.0% | 2.0% | 96.49 | 0.598 |
| 3 | Brigatinib | 97.8% | 2.2% | 82.96 | 0.513 |
| 4 | Dasatinib | 97.5% | 2.5% | 87.97 | 0.699 |
| 5 | Tivozanib | 97.2% | 2.8% | 92.42 | 0.673 |
| 6 | Gilteritinib | 96.6% | 3.4% | 88.97 | 0.506 |
| 7 | Ibrutinib | 96.5% | 3.5% | 94.74 | 0.723 |
| 8 | Vandetanib | 95.3% | 4.7% | 95.74 | 0.723 |
| 9 | Zanubrutinib | 93.4% | 6.6% | 98.24 | 0.788 |
| 10 | Pacritinib | 93.0% | 7.0% | 88.64 | 0.452 |
| 11 | Ponatinib | 91.7% | 8.3% | 78.23 | 0.534 |
| 12 | Dabrafenib | 89.4% | 10.6% | 94.74 | 0.633 |
| 13 | Pirtobrutinib | 88.1% | 11.9% | 99.49 | 0.656 |
| 14 | Ceritinib | 86.9% | 13.1% | 95.44 | 0.618 |
| 15 | Osimertinib | 85.8% | 14.2% | 97.24 | 0.733 |
| 16 | Canertinib | 80.2% | 19.8% | 96.49 | 0.671 |
| 17 | Entrectinib | 71.1% | 28.9% | 93.69 | 0.671 |
| 18 | Ripretinib | 67.7% | 32.3% | 92.95 | 0.674 |
| 19 | Lenvatinib | 66.1% | 33.9% | 97.74 | 0.726 |
| 20 | Nilotinib | 63.0% | 37.0% | 96.49 | 0.765 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 0.33
- Epithelial log2(TPM+1): 2.34
- Fold change: -2.02
- Status: Downregulated
Selectivity landscape vs inhibition on PTK6
Each point is one of the 92 approved drugs; color = inhibition % on PTK6.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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