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CDK3/CCNC(CDK3/cyclin C)

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UniProt CDK3: Q00526; cyclin C: P24863 · PDB · AlphaFold (Q00526), AlphaFold (P24863) · Substrate: CHKtide · Clone: full length / full length

Top inhibitors

MeasuredDerived
#DrugInhibitionResidualKISSGini
1Rabusertib80.3%19.7%98.740.687
2Repotrectinib73.4%26.6%84.210.608
3Pacritinib70.5%29.5%88.640.452
4Ceritinib60.0%40.0%95.440.618
5Upadacitinib59.0%41.0%97.980.663
6Fedratinib52.6%47.4%96.210.576
7Defactinib50.1%49.9%92.680.450
8Darovasertib40.4%59.6%96.990.719
9Paxalisib26.6%73.4%99.750.609
10Selpercatinib22.5%77.5%96.720.635
11Mobocertinib20.4%79.6%97.220.757
12Entrectinib20.2%79.8%93.690.671
13Crizotinib19.8%80.2%91.390.581
14Ponatinib19.3%80.7%78.230.534
15Abrocitinib17.4%82.6%99.500.581
16Pemigatinib15.0%85.0%98.230.718
17Neratinib14.4%85.6%93.180.597
18Capivasertib14.1%85.9%96.480.644
19Avapritinib13.4%86.6%97.730.644
20Deucravacitinib12.7%87.3%98.990.718

Paralog block

No paralog group registered for this kinase.

EMT expression

MeasuredDerived

Not in the EMT expression panel.

Selectivity landscape vs inhibition on CDK3/CCNC

MeasuredDerived

Each point is one of the 92 approved drugs; color = inhibition % on CDK3/CCNC.

3D structure

Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.

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