CDK4/CCND2(CDK4/cyclin D2)
Sign in to save this workspaceUniProt CDK4: P11802; Cyclin D2: P30279 · PDB · AlphaFold (P11802), AlphaFold (P30279) · Substrate: RB Protein · Clone: full-length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Pacritinib | 89.0% | 11.0% | 88.64 | 0.452 |
| 2 | Defactinib | 59.5% | 40.5% | 92.68 | 0.450 |
| 3 | Infigratinib | 30.4% | 69.6% | 98.24 | 0.710 |
| 4 | Ponatinib | 29.7% | 70.3% | 78.23 | 0.534 |
| 5 | Fedratinib | 23.3% | 76.8% | 96.21 | 0.576 |
| 6 | Pemigatinib | 22.8% | 77.2% | 98.23 | 0.718 |
| 7 | Crizotinib | 17.4% | 82.6% | 91.39 | 0.581 |
| 8 | Capivasertib | 15.5% | 84.5% | 96.48 | 0.644 |
| 9 | Rabusertib | 14.8% | 85.2% | 98.74 | 0.687 |
| 10 | Ripretinib | 12.3% | 87.7% | 92.95 | 0.674 |
| 11 | Avapritinib | 11.4% | 88.6% | 97.73 | 0.644 |
| 12 | Tucatinib | 10.0% | 90.0% | 99.75 | 0.652 |
| 13 | Mitapivat | 8.3% | 91.7% | 100.00 | 0.625 |
| 14 | Canertinib | 7.0% | 93.0% | 96.49 | 0.671 |
| 15 | Zanubrutinib | 7.0% | 93.0% | 98.24 | 0.788 |
| 16 | Asciminib | 7.0% | 93.0% | 100.00 | 0.602 |
| 17 | Ceritinib | 6.6% | 93.4% | 95.44 | 0.618 |
| 18 | Neratinib | 6.4% | 93.6% | 93.18 | 0.597 |
| 19 | Upadacitinib | 5.9% | 94.1% | 97.98 | 0.663 |
| 20 | Entrectinib | 5.6% | 94.4% | 93.69 | 0.671 |
Paralog block
No paralog group registered for this kinase.
EMT expression
Not in the EMT expression panel.
Selectivity landscape vs inhibition on CDK4/CCND2
Each point is one of the 92 approved drugs; color = inhibition % on CDK4/CCND2.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
Annotations
Sign in to read and post annotations.
Loading…