CHEK1(CHK1)
Sign in to save this workspaceUniProt O14757 · PDB · AlphaFold · Substrate: CHKtide · Clone: full length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Rabusertib | 99.4% | 0.6% | 98.74 | 0.687 |
| 2 | Paxalisib | 95.2% | 4.8% | 99.75 | 0.609 |
| 3 | Brigatinib | 94.7% | 5.3% | 82.96 | 0.513 |
| 4 | Sunitinib | 84.2% | 15.8% | 91.73 | 0.524 |
| 5 | Nintedanib | 62.0% | 38.0% | 90.23 | 0.608 |
| 6 | Midostaurin | 60.1% | 39.9% | 78.64 | 0.500 |
| 7 | Netarsudil | 53.2% | 46.8% | 93.22 | 0.676 |
| 8 | Bosutinib | 40.7% | 59.3% | 87.22 | 0.555 |
| 9 | Gilteritinib | 30.2% | 69.8% | 88.97 | 0.506 |
| 10 | Avapritinib | 26.4% | 73.6% | 97.73 | 0.644 |
| 11 | Defactinib | 23.2% | 76.8% | 92.68 | 0.450 |
| 12 | Crizotinib | 22.5% | 77.5% | 91.39 | 0.581 |
| 13 | Capivasertib | 20.4% | 79.6% | 96.48 | 0.644 |
| 14 | Vandetanib | 19.7% | 80.3% | 95.74 | 0.723 |
| 15 | Fedratinib | 19.3% | 80.7% | 96.21 | 0.576 |
| 16 | Selpercatinib | 17.6% | 82.4% | 96.72 | 0.635 |
| 17 | Palbociclib | 17.4% | 82.6% | 98.75 | 0.673 |
| 18 | Axitinib | 15.8% | 84.2% | 93.23 | 0.688 |
| 19 | Baricitinib | 15.1% | 84.9% | 97.99 | 0.616 |
| 20 | Dacomitinib | 14.9% | 85.1% | 97.99 | 0.664 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 4.47
- Epithelial log2(TPM+1): 4.74
- Fold change: -0.27
- Status: No significant change
Selectivity landscape vs inhibition on CHEK1
Each point is one of the 92 approved drugs; color = inhibition % on CHEK1.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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