DCLK1(DCAMKL1)
Sign in to save this workspaceUniProt O15075 · PDB · AlphaFold · Substrate: ZIPtide · Clone: full-length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Lorlatinib | 77.5% | 22.5% | 97.24 | 0.694 |
| 2 | Crizotinib | 69.0% | 31.0% | 91.39 | 0.581 |
| 3 | Ceritinib | 65.2% | 34.8% | 95.44 | 0.618 |
| 4 | Baricitinib | 64.7% | 35.3% | 97.99 | 0.616 |
| 5 | Brigatinib | 58.4% | 41.6% | 82.96 | 0.513 |
| 6 | Ruxolitinib | 39.3% | 60.7% | 98.25 | 0.592 |
| 7 | Fedratinib | 36.5% | 63.5% | 96.21 | 0.576 |
| 8 | Dabrafenib | 25.4% | 74.6% | 94.74 | 0.633 |
| 9 | Sunitinib | 23.3% | 76.7% | 91.73 | 0.524 |
| 10 | Palbociclib | 18.5% | 81.5% | 98.75 | 0.673 |
| 11 | Abemaciclib | 17.9% | 82.1% | 91.48 | 0.563 |
| 12 | Pemigatinib | 17.6% | 82.4% | 98.23 | 0.718 |
| 13 | Gilteritinib | 15.4% | 84.6% | 88.97 | 0.506 |
| 14 | Entrectinib | 13.9% | 86.1% | 93.69 | 0.671 |
| 15 | Defactinib | 10.8% | 89.2% | 92.68 | 0.450 |
| 16 | Repotrectinib | 10.4% | 89.6% | 84.21 | 0.608 |
| 17 | Alectinib | 9.5% | 90.5% | 95.49 | 0.651 |
| 18 | Midostaurin | 9.5% | 90.5% | 78.64 | 0.500 |
| 19 | Upadacitinib | 9.2% | 90.8% | 97.98 | 0.663 |
| 20 | Bosutinib | 9.0% | 91.0% | 87.22 | 0.555 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 1.78
- Epithelial log2(TPM+1): 0.90
- Fold change: 0.88
- Status: No significant change
Selectivity landscape vs inhibition on DCLK1
Each point is one of the 92 approved drugs; color = inhibition % on DCLK1.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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