UniProt Q9NR20 · PDB · AlphaFold · Substrate: DYRKtide · Clone: full length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Avapritinib | 52.6% | 47.4% | 97.73 | 0.644 |
| 2 | Abemaciclib | 21.7% | 78.3% | 91.48 | 0.563 |
| 3 | Defactinib | 21.0% | 79.0% | 92.68 | 0.450 |
| 4 | Gedatolisib | 13.4% | 86.6% | 99.75 | 0.611 |
| 5 | Pirtobrutinib | 10.4% | 89.6% | 99.49 | 0.656 |
| 6 | Pacritinib | 9.6% | 90.4% | 88.64 | 0.452 |
| 7 | Alectinib | 9.3% | 90.7% | 95.49 | 0.651 |
| 8 | Mobocertinib | 8.5% | 91.5% | 97.22 | 0.757 |
| 9 | Capivasertib | 8.0% | 92.0% | 96.48 | 0.644 |
| 10 | Infigratinib | 7.6% | 92.4% | 98.24 | 0.710 |
| 11 | Fostamatinib | 7.6% | 92.4% | 96.74 | 0.613 |
| 12 | Tenalisib | 7.5% | 92.5% | 97.98 | 0.702 |
| 13 | Ceritinib | 7.4% | 92.6% | 95.44 | 0.618 |
| 14 | Neratinib | 7.2% | 92.8% | 93.18 | 0.597 |
| 15 | Lapatinib | 6.9% | 93.1% | 99.25 | 0.616 |
| 16 | Midostaurin | 6.6% | 93.4% | 78.64 | 0.500 |
| 17 | Dacomitinib | 6.0% | 94.0% | 97.99 | 0.664 |
| 18 | Brigatinib | 5.9% | 94.1% | 82.96 | 0.513 |
| 19 | Leniolisib | 5.8% | 94.2% | 100.00 | 0.604 |
| 20 | Selumetinib | 5.6% | 94.4% | 100.00 | 0.640 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 4.78
- Epithelial log2(TPM+1): 4.27
- Fold change: 0.51
- Status: No significant change
Selectivity landscape vs inhibition on DYRK4
Each point is one of the 92 approved drugs; color = inhibition % on DYRK4.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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