ERBB2(ERBB2/HER2)
Sign in to save this workspaceUniProt P04626 · PDB · AlphaFold · Substrate: pEY + Mn · Clone: aa679-1255
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 4.63
- Epithelial log2(TPM+1): 5.17
- Fold change: -0.54
- Status: No significant change
Selectivity landscape vs inhibition on ERBB2
Each point is one of the 92 approved drugs; color = inhibition % on ERBB2.
Mutation lollipop
Cancer-associated mutations plotted by residue position. Marker size + color scale with the number of distinct cancer reports.
Variants (9)
Mutation × cancer associations
| Mutation | Cancer | Organ | Source |
|---|---|---|---|
| A775 | carcinoma_breast | Breast | ref |
| D769H | carcinoma_breast | Breast | ref |
| D769Y | carcinoma_breast | Breast | ref |
| G776INSYVMA | carcinoma_lung | Lung | ref |
| G778INSCG | carcinoma_lung | Lung | ref |
| P1170A | carcinoma_breast | Breast | ref |
| P780 | carcinoma_breast | Breast | ref |
| R896C | carcinoma_breast | Breast | ref |
| V777 | carcinoma_breast | Breast | ref |
| V777L | carcinoma_breast | Breast | ref |
| V956R | carcinoma_breast | Breast | ref |
| Y781INSGSP | carcinoma_lung | Lung | ref |
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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