UniProt P08069 · PDB · AlphaFold · Substrate: pEY + Mn · Clone: aa 960-1367
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Ceritinib | 98.1% | 1.9% | 95.44 | 0.618 |
| 2 | Gilteritinib | 93.4% | 6.6% | 88.97 | 0.506 |
| 3 | Brigatinib | 92.0% | 8.0% | 82.96 | 0.513 |
| 4 | Entrectinib | 86.5% | 13.5% | 93.69 | 0.671 |
| 5 | Fostamatinib | 82.7% | 17.3% | 96.74 | 0.613 |
| 6 | Pacritinib | 75.5% | 24.5% | 88.64 | 0.452 |
| 7 | Crizotinib | 72.3% | 27.7% | 91.39 | 0.581 |
| 8 | Nintedanib | 70.7% | 29.3% | 90.23 | 0.608 |
| 9 | Lorlatinib | 67.6% | 32.4% | 97.24 | 0.694 |
| 10 | Repotrectinib | 61.6% | 38.4% | 84.21 | 0.608 |
| 11 | Osimertinib | 56.9% | 43.1% | 97.24 | 0.733 |
| 12 | Defactinib | 50.9% | 49.1% | 92.68 | 0.450 |
| 13 | Fedratinib | 49.8% | 50.2% | 96.21 | 0.576 |
| 14 | Alectinib | 48.7% | 51.3% | 95.49 | 0.651 |
| 15 | Neratinib | 38.6% | 61.4% | 93.18 | 0.597 |
| 16 | Sunitinib | 38.1% | 61.9% | 91.73 | 0.524 |
| 17 | Pralsetinib | 26.1% | 73.9% | 93.43 | 0.643 |
| 18 | Alpelisib | 22.3% | 77.7% | 97.22 | 0.720 |
| 19 | Vemurafenib | 19.5% | 80.5% | 96.49 | 0.598 |
| 20 | Abemaciclib | 17.3% | 82.7% | 91.48 | 0.563 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 3.55
- Epithelial log2(TPM+1): 2.93
- Fold change: 0.63
- Status: No significant change
Selectivity landscape vs inhibition on IGF1R
Each point is one of the 92 approved drugs; color = inhibition % on IGF1R.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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