MAPKAPK2
Sign in to save this workspaceUniProt P49137 · PDB · AlphaFold · Substrate: Glycogen Synthase-derived peptide · Clone: ful length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Asciminib | 15.3% | 84.7% | 100.00 | 0.602 |
| 2 | Acalabrutinib | 13.3% | 86.7% | 99.50 | 0.670 |
| 3 | Paxalisib | 12.2% | 87.8% | 99.75 | 0.609 |
| 4 | Lapatinib | 11.5% | 88.5% | 99.25 | 0.616 |
| 5 | Neratinib | 11.5% | 88.5% | 93.18 | 0.597 |
| 6 | Ruxolitinib | 11.3% | 88.7% | 98.25 | 0.592 |
| 7 | Ponatinib | 10.7% | 89.3% | 78.23 | 0.534 |
| 8 | Gedatolisib | 10.4% | 89.6% | 99.75 | 0.611 |
| 9 | Defactinib | 10.2% | 89.8% | 92.68 | 0.450 |
| 10 | Brigatinib | 10.0% | 90.0% | 82.96 | 0.513 |
| 11 | Pirtobrutinib | 9.8% | 90.2% | 99.49 | 0.656 |
| 12 | Crizotinib | 9.8% | 90.2% | 91.39 | 0.581 |
| 13 | Tenalisib | 9.4% | 90.6% | 97.98 | 0.702 |
| 14 | Vemurafenib | 9.3% | 90.7% | 96.49 | 0.598 |
| 15 | Idelalisib | 8.7% | 91.3% | 100.00 | 0.701 |
| 16 | Duvelisib | 8.5% | 91.5% | 100.00 | 0.716 |
| 17 | Dacomitinib | 7.8% | 92.2% | 97.99 | 0.664 |
| 18 | Abrocitinib | 7.4% | 92.6% | 99.50 | 0.581 |
| 19 | Sorafenib | 7.3% | 92.7% | 96.72 | 0.776 |
| 20 | Avapritinib | 6.9% | 93.1% | 97.73 | 0.644 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 5.51
- Epithelial log2(TPM+1): 4.85
- Fold change: 0.66
- Status: No significant change
Selectivity landscape vs inhibition on MAPKAPK2
Each point is one of the 92 approved drugs; color = inhibition % on MAPKAPK2.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
Annotations
Sign in to read and post annotations.
Loading…