UniProt Q96GX5 · PDB · AlphaFold · Substrate: ARPP19 · Clone: full length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Lazertinib | 54.0% | 46.0% | 97.47 | 0.674 |
| 2 | Netarsudil | 42.0% | 58.0% | 93.22 | 0.676 |
| 3 | Sunitinib | 30.1% | 69.9% | 91.73 | 0.524 |
| 4 | Pacritinib | 26.2% | 73.8% | 88.64 | 0.452 |
| 5 | Midostaurin | 20.0% | 80.0% | 78.64 | 0.500 |
| 6 | Gilteritinib | 17.8% | 82.2% | 88.97 | 0.506 |
| 7 | Defactinib | 17.7% | 82.3% | 92.68 | 0.450 |
| 8 | Gedatolisib | 14.3% | 85.7% | 99.75 | 0.611 |
| 9 | Pexidartinib | 12.7% | 87.3% | 99.49 | 0.631 |
| 10 | Abemaciclib | 9.4% | 90.6% | 91.48 | 0.563 |
| 11 | Alpelisib | 8.1% | 91.9% | 97.22 | 0.720 |
| 12 | Bosutinib | 6.5% | 93.5% | 87.22 | 0.555 |
| 13 | Pirtobrutinib | 6.0% | 94.0% | 99.49 | 0.656 |
| 14 | Crizotinib | 5.9% | 94.1% | 91.39 | 0.581 |
| 15 | Tucatinib | 5.9% | 94.1% | 99.75 | 0.652 |
| 16 | Ibrutinib | 5.4% | 94.6% | 94.74 | 0.723 |
| 17 | Dacomitinib | 5.2% | 94.8% | 97.99 | 0.664 |
| 18 | Osimertinib | 5.1% | 94.9% | 97.24 | 0.733 |
| 19 | Pralsetinib | 4.9% | 95.1% | 93.43 | 0.643 |
| 20 | Binimetinib | 3.8% | 96.2% | 100.00 | 0.689 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 3.73
- Epithelial log2(TPM+1): 3.63
- Fold change: 0.10
- Status: No significant change
Selectivity landscape vs inhibition on MASTL
Each point is one of the 92 approved drugs; color = inhibition % on MASTL.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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