MKNK1(MNK1)
Sign in to save this workspaceUniProt Q9BUB5 · PDB · AlphaFold · Substrate: MBP · Clone: full length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Osimertinib | 86.2% | 13.8% | 97.24 | 0.733 |
| 2 | Canertinib | 82.5% | 17.5% | 96.49 | 0.671 |
| 3 | Dacomitinib | 68.8% | 31.2% | 97.99 | 0.664 |
| 4 | Gefitinib | 68.7% | 31.3% | 99.25 | 0.650 |
| 5 | Vemurafenib | 67.0% | 33.0% | 96.49 | 0.598 |
| 6 | Vandetanib | 64.5% | 35.5% | 95.74 | 0.723 |
| 7 | Afatinib | 57.0% | 43.0% | 98.50 | 0.709 |
| 8 | Ponatinib | 51.4% | 48.6% | 78.23 | 0.534 |
| 9 | Gilteritinib | 48.3% | 51.7% | 88.97 | 0.506 |
| 10 | Erlotinib | 47.6% | 52.4% | 99.75 | 0.695 |
| 11 | Avapritinib | 45.5% | 54.5% | 97.73 | 0.644 |
| 12 | Abemaciclib | 41.3% | 58.7% | 91.48 | 0.563 |
| 13 | Sorafenib | 40.0% | 60.0% | 96.72 | 0.776 |
| 14 | Pacritinib | 30.2% | 69.8% | 88.64 | 0.452 |
| 15 | Alectinib | 26.0% | 74.0% | 95.49 | 0.651 |
| 16 | Cabozantinib | 25.8% | 74.2% | 92.73 | 0.751 |
| 17 | Axitinib | 24.9% | 75.1% | 93.23 | 0.688 |
| 18 | Apatinib | 24.5% | 75.5% | 97.73 | 0.704 |
| 19 | Upadacitinib | 22.7% | 77.3% | 97.98 | 0.663 |
| 20 | Rabusertib | 19.1% | 80.9% | 98.74 | 0.687 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 4.17
- Epithelial log2(TPM+1): 4.14
- Fold change: 0.03
- Status: No significant change
Selectivity landscape vs inhibition on MKNK1
Each point is one of the 92 approved drugs; color = inhibition % on MKNK1.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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