UniProt Q8WUN5 · PDB · AlphaFold · Substrate: MBP · Clone: full-length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Neratinib | 46.3% | 53.7% | 93.18 | 0.597 |
| 2 | Pacritinib | 43.0% | 57.0% | 88.64 | 0.452 |
| 3 | Defactinib | 36.0% | 64.0% | 92.68 | 0.450 |
| 4 | Crizotinib | 24.8% | 75.2% | 91.39 | 0.581 |
| 5 | Gilteritinib | 23.0% | 77.0% | 88.97 | 0.506 |
| 6 | Fostamatinib | 19.6% | 80.4% | 96.74 | 0.613 |
| 7 | Capivasertib | 17.9% | 82.1% | 96.48 | 0.644 |
| 8 | Dabrafenib | 16.3% | 83.7% | 94.74 | 0.633 |
| 9 | Selpercatinib | 15.6% | 84.4% | 96.72 | 0.635 |
| 10 | Tivozanib | 15.5% | 84.5% | 92.42 | 0.673 |
| 11 | Abemaciclib | 14.5% | 85.5% | 91.48 | 0.563 |
| 12 | Canertinib | 14.4% | 85.6% | 96.49 | 0.671 |
| 13 | Imatinib | 13.5% | 86.5% | 99.00 | 0.718 |
| 14 | Deucravacitinib | 13.2% | 86.8% | 98.99 | 0.718 |
| 15 | Remibrutinib | 12.3% | 87.7% | 99.50 | 0.721 |
| 16 | Ponatinib | 11.2% | 88.8% | 78.23 | 0.534 |
| 17 | Bosutinib | 10.4% | 89.6% | 87.22 | 0.555 |
| 18 | Ceritinib | 10.0% | 90.0% | 95.44 | 0.618 |
| 19 | Ibrutinib | 9.5% | 90.5% | 94.74 | 0.723 |
| 20 | Sirolimus | 8.6% | 91.4% | 100.00 | 0.708 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 2.86
- Epithelial log2(TPM+1): 3.35
- Fold change: -0.49
- Status: No significant change
Selectivity landscape vs inhibition on NEK3
Each point is one of the 92 approved drugs; color = inhibition % on NEK3.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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