UniProt O75914 · PDB · AlphaFold · Substrate: PAKtide · Clone: full length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Neratinib | 88.3% | 11.7% | 93.18 | 0.597 |
| 2 | Midostaurin | 43.0% | 57.0% | 78.64 | 0.500 |
| 3 | Defactinib | 40.8% | 59.2% | 92.68 | 0.450 |
| 4 | Vemurafenib | 39.9% | 60.1% | 96.49 | 0.598 |
| 5 | Pralsetinib | 34.8% | 65.2% | 93.43 | 0.643 |
| 6 | Pacritinib | 27.9% | 72.1% | 88.64 | 0.452 |
| 7 | Bosutinib | 25.0% | 75.0% | 87.22 | 0.555 |
| 8 | Fostamatinib | 20.0% | 80.0% | 96.74 | 0.613 |
| 9 | Pirtobrutinib | 19.4% | 80.6% | 99.49 | 0.656 |
| 10 | Brigatinib | 13.0% | 87.0% | 82.96 | 0.513 |
| 11 | Mobocertinib | 12.8% | 87.2% | 97.22 | 0.757 |
| 12 | Fedratinib | 12.7% | 87.3% | 96.21 | 0.576 |
| 13 | Gedatolisib | 12.3% | 87.7% | 99.75 | 0.611 |
| 14 | Lapatinib | 10.9% | 89.1% | 99.25 | 0.616 |
| 15 | Abemaciclib | 10.7% | 89.3% | 91.48 | 0.563 |
| 16 | Erdafitinib | 10.5% | 89.5% | 95.71 | 0.737 |
| 17 | Capivasertib | 9.9% | 90.1% | 96.48 | 0.644 |
| 18 | Leniolisib | 9.3% | 90.7% | 100.00 | 0.604 |
| 19 | Ibrutinib | 9.0% | 91.0% | 94.74 | 0.723 |
| 20 | Erlotinib | 8.9% | 91.1% | 99.75 | 0.695 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 0.70
- Epithelial log2(TPM+1): 0.34
- Fold change: 0.36
- Status: No significant change
Selectivity landscape vs inhibition on PAK3
Each point is one of the 92 approved drugs; color = inhibition % on PAK3.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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