UniProt Q9NQU5 · PDB · AlphaFold · Substrate: PAKtide · Clone: full-length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Pralsetinib | 41.3% | 58.7% | 93.43 | 0.643 |
| 2 | Midostaurin | 38.3% | 61.7% | 78.64 | 0.500 |
| 3 | Defactinib | 33.3% | 66.7% | 92.68 | 0.450 |
| 4 | Axitinib | 23.8% | 76.2% | 93.23 | 0.688 |
| 5 | Capivasertib | 23.5% | 76.5% | 96.48 | 0.644 |
| 6 | Repotrectinib | 21.5% | 78.5% | 84.21 | 0.608 |
| 7 | Avapritinib | 19.5% | 80.5% | 97.73 | 0.644 |
| 8 | Brigatinib | 17.9% | 82.1% | 82.96 | 0.513 |
| 9 | Darovasertib | 17.0% | 83.0% | 96.99 | 0.719 |
| 10 | Neratinib | 15.5% | 84.5% | 93.18 | 0.597 |
| 11 | Gilteritinib | 15.4% | 84.6% | 88.97 | 0.506 |
| 12 | Baricitinib | 14.4% | 85.6% | 97.99 | 0.616 |
| 13 | Canertinib | 13.0% | 87.0% | 96.49 | 0.671 |
| 14 | Crizotinib | 12.6% | 87.4% | 91.39 | 0.581 |
| 15 | Pacritinib | 12.5% | 87.5% | 88.64 | 0.452 |
| 16 | Fedratinib | 11.3% | 88.7% | 96.21 | 0.576 |
| 17 | Abemaciclib | 10.6% | 89.4% | 91.48 | 0.563 |
| 18 | Fostamatinib | 10.3% | 89.7% | 96.74 | 0.613 |
| 19 | Remibrutinib | 10.2% | 89.8% | 99.50 | 0.721 |
| 20 | Alpelisib | 9.2% | 90.8% | 97.22 | 0.720 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 0.51
- Epithelial log2(TPM+1): 2.12
- Fold change: -1.61
- Status: Downregulated
Selectivity landscape vs inhibition on PAK6
Each point is one of the 92 approved drugs; color = inhibition % on PAK6.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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