PRKACA(PKA)
Sign in to save this workspaceUniProt P17612 · PDB · AlphaFold · Substrate: PKA sub · Clone: full-length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Capivasertib | 99.7% | 0.3% | 96.48 | 0.644 |
| 2 | Netarsudil | 96.6% | 3.4% | 93.22 | 0.676 |
| 3 | Baricitinib | 90.9% | 9.1% | 97.99 | 0.616 |
| 4 | Midostaurin | 79.8% | 20.2% | 78.64 | 0.500 |
| 5 | Ponatinib | 70.9% | 29.1% | 78.23 | 0.534 |
| 6 | Ruxolitinib | 45.5% | 54.5% | 98.25 | 0.592 |
| 7 | Abrocitinib | 37.8% | 62.2% | 99.50 | 0.581 |
| 8 | Darovasertib | 32.9% | 67.1% | 96.99 | 0.719 |
| 9 | Pacritinib | 28.8% | 71.2% | 88.64 | 0.452 |
| 10 | Defactinib | 23.7% | 76.3% | 92.68 | 0.450 |
| 11 | Bosutinib | 22.4% | 77.6% | 87.22 | 0.555 |
| 12 | Fostamatinib | 20.9% | 79.1% | 96.74 | 0.613 |
| 13 | Brigatinib | 17.2% | 82.8% | 82.96 | 0.513 |
| 14 | Gilteritinib | 17.0% | 83.0% | 88.97 | 0.506 |
| 15 | Pralsetinib | 15.1% | 84.9% | 93.43 | 0.643 |
| 16 | Sunitinib | 13.7% | 86.3% | 91.73 | 0.524 |
| 17 | Abemaciclib | 11.3% | 88.7% | 91.48 | 0.563 |
| 18 | Selpercatinib | 8.3% | 91.7% | 96.72 | 0.635 |
| 19 | Lenvatinib | 8.0% | 92.0% | 97.74 | 0.726 |
| 20 | Alectinib | 7.9% | 92.1% | 95.49 | 0.651 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 5.85
- Epithelial log2(TPM+1): 4.95
- Fold change: 0.90
- Status: No significant change
Selectivity landscape vs inhibition on PRKACA
Each point is one of the 92 approved drugs; color = inhibition % on PRKACA.
Variants (1)
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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