DSTYK(RIPK5)
Sign in to save this workspaceUniProt Q6XUX3 · PDB · AlphaFold · Substrate: MBP · Clone: full length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Ceritinib | 36.8% | 63.2% | 95.44 | 0.618 |
| 2 | Crizotinib | 30.0% | 70.0% | 91.39 | 0.581 |
| 3 | Pacritinib | 26.2% | 73.8% | 88.64 | 0.452 |
| 4 | Mobocertinib | 22.0% | 78.0% | 97.22 | 0.757 |
| 5 | Erdafitinib | 20.5% | 79.5% | 95.71 | 0.737 |
| 6 | Gilteritinib | 20.1% | 79.9% | 88.97 | 0.506 |
| 7 | Selpercatinib | 20.0% | 80.0% | 96.72 | 0.635 |
| 8 | Neratinib | 19.8% | 80.3% | 93.18 | 0.597 |
| 9 | Fostamatinib | 16.5% | 83.5% | 96.74 | 0.613 |
| 10 | Gedatolisib | 16.3% | 83.7% | 99.75 | 0.611 |
| 11 | Alpelisib | 15.8% | 84.2% | 97.22 | 0.720 |
| 12 | Deucravacitinib | 15.5% | 84.5% | 98.99 | 0.718 |
| 13 | Capmatinib | 14.0% | 86.0% | 99.75 | 0.582 |
| 14 | Pirtobrutinib | 13.6% | 86.4% | 99.49 | 0.656 |
| 15 | Baricitinib | 13.4% | 86.6% | 97.99 | 0.616 |
| 16 | Imatinib | 13.2% | 86.8% | 99.00 | 0.718 |
| 17 | Apatinib | 13.1% | 86.9% | 97.73 | 0.704 |
| 18 | Paxalisib | 12.7% | 87.3% | 99.75 | 0.609 |
| 19 | Ibrutinib | 12.4% | 87.6% | 94.74 | 0.723 |
| 20 | Entrectinib | 11.4% | 88.6% | 93.69 | 0.671 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 3.22
- Epithelial log2(TPM+1): 2.42
- Fold change: 0.79
- Status: No significant change
Selectivity landscape vs inhibition on DSTYK
Each point is one of the 92 approved drugs; color = inhibition % on DSTYK.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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