UniProt O75116 · PDB · AlphaFold · Substrate: Long S6 Kinase substrate peptide · Clone: aa 5-554
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Netarsudil | 96.0% | 4.0% | 93.22 | 0.676 |
| 2 | Capivasertib | 85.6% | 14.4% | 96.48 | 0.644 |
| 3 | Baricitinib | 76.5% | 23.5% | 97.99 | 0.616 |
| 4 | Ruxolitinib | 49.5% | 50.5% | 98.25 | 0.592 |
| 5 | Upadacitinib | 39.6% | 60.4% | 97.98 | 0.663 |
| 6 | Abemaciclib | 36.6% | 63.4% | 91.48 | 0.563 |
| 7 | Abrocitinib | 26.6% | 73.4% | 99.50 | 0.581 |
| 8 | Ponatinib | 26.5% | 73.5% | 78.23 | 0.534 |
| 9 | Gilteritinib | 24.4% | 75.6% | 88.97 | 0.506 |
| 10 | Tivozanib | 22.3% | 77.7% | 92.42 | 0.673 |
| 11 | Bosutinib | 20.8% | 79.2% | 87.22 | 0.555 |
| 12 | Brigatinib | 14.1% | 85.9% | 82.96 | 0.513 |
| 13 | Sunitinib | 13.9% | 86.1% | 91.73 | 0.524 |
| 14 | Axitinib | 13.0% | 87.0% | 93.23 | 0.688 |
| 15 | Pacritinib | 12.1% | 87.9% | 88.64 | 0.452 |
| 16 | Repotrectinib | 11.5% | 88.5% | 84.21 | 0.608 |
| 17 | Neratinib | 10.5% | 89.5% | 93.18 | 0.597 |
| 18 | Defactinib | 9.2% | 90.8% | 92.68 | 0.450 |
| 19 | Lazertinib | 8.9% | 91.1% | 97.47 | 0.674 |
| 20 | Fostamatinib | 8.7% | 91.3% | 96.74 | 0.613 |
Paralog block
ROCK1, ROCK2
EMT expression
- Mesenchymal log2(TPM+1): 4.14
- Epithelial log2(TPM+1): 3.63
- Fold change: 0.51
- Status: No significant change
Selectivity landscape vs inhibition on ROCK2
Each point is one of the 92 approved drugs; color = inhibition % on ROCK2.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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