UniProt O00141 · PDB · AlphaFold · Substrate: Crosstide · Clone: Catalytic (60-431)
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Abemaciclib | 57.9% | 42.1% | 91.48 | 0.563 |
| 2 | Netarsudil | 45.2% | 54.8% | 93.22 | 0.676 |
| 3 | Capivasertib | 24.0% | 76.0% | 96.48 | 0.644 |
| 4 | Fostamatinib | 17.2% | 82.8% | 96.74 | 0.613 |
| 5 | Defactinib | 16.2% | 83.8% | 92.68 | 0.450 |
| 6 | Pacritinib | 9.7% | 90.3% | 88.64 | 0.452 |
| 7 | Pralsetinib | 8.9% | 91.1% | 93.43 | 0.643 |
| 8 | Upadacitinib | 8.8% | 91.2% | 97.98 | 0.663 |
| 9 | Capmatinib | 8.7% | 91.3% | 99.75 | 0.582 |
| 10 | Pemigatinib | 8.0% | 92.0% | 98.23 | 0.718 |
| 11 | Pirtobrutinib | 7.3% | 92.7% | 99.49 | 0.656 |
| 12 | Crizotinib | 6.9% | 93.1% | 91.39 | 0.581 |
| 13 | Asciminib | 6.6% | 93.4% | 100.00 | 0.602 |
| 14 | Futibatinib | 6.2% | 93.8% | 98.48 | 0.718 |
| 15 | Apatinib | 5.7% | 94.3% | 97.73 | 0.704 |
| 16 | Tofacitinib | 5.5% | 94.5% | 99.25 | 0.684 |
| 17 | Regorafenib | 5.5% | 94.5% | 95.99 | 0.719 |
| 18 | Ripretinib | 5.4% | 94.6% | 92.95 | 0.674 |
| 19 | Alectinib | 5.1% | 94.9% | 95.49 | 0.651 |
| 20 | Everolimus | 5.0% | 95.0% | 100.00 | 0.706 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 5.57
- Epithelial log2(TPM+1): 2.69
- Fold change: 2.88
- Status: Upregulated
Selectivity landscape vs inhibition on SGK1
Each point is one of the 92 approved drugs; color = inhibition % on SGK1.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
Annotations
Sign in to read and post annotations.
Loading…