UniProt Q9H0K1 · PDB · AlphaFold · Substrate: AMARA peptide · Clone: full length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Bosutinib | 99.6% | 0.4% | 87.22 | 0.555 |
| 2 | Nintedanib | 99.4% | 0.6% | 90.23 | 0.608 |
| 3 | Midostaurin | 98.8% | 1.2% | 78.64 | 0.500 |
| 4 | Brigatinib | 98.4% | 1.6% | 82.96 | 0.513 |
| 5 | Dasatinib | 97.5% | 2.5% | 87.97 | 0.699 |
| 6 | Fedratinib | 96.8% | 3.2% | 96.21 | 0.576 |
| 7 | Pacritinib | 93.0% | 7.0% | 88.64 | 0.452 |
| 8 | Vandetanib | 86.8% | 13.2% | 95.74 | 0.723 |
| 9 | Dabrafenib | 85.0% | 15.0% | 94.74 | 0.633 |
| 10 | Crizotinib | 80.4% | 19.6% | 91.39 | 0.581 |
| 11 | Repotrectinib | 76.1% | 23.9% | 84.21 | 0.608 |
| 12 | Canertinib | 73.5% | 26.5% | 96.49 | 0.671 |
| 13 | Rabusertib | 72.1% | 27.9% | 98.74 | 0.687 |
| 14 | Sunitinib | 72.0% | 28.0% | 91.73 | 0.524 |
| 15 | Ponatinib | 71.7% | 28.3% | 78.23 | 0.534 |
| 16 | Gilteritinib | 70.2% | 29.8% | 88.97 | 0.506 |
| 17 | Dacomitinib | 69.1% | 30.9% | 97.99 | 0.664 |
| 18 | Defactinib | 67.0% | 33.0% | 92.68 | 0.450 |
| 19 | Neratinib | 64.4% | 35.6% | 93.18 | 0.597 |
| 20 | Gefitinib | 61.4% | 38.6% | 99.25 | 0.650 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 2.97
- Epithelial log2(TPM+1): 2.64
- Fold change: 0.33
- Status: No significant change
Selectivity landscape vs inhibition on SIK2
Each point is one of the 92 approved drugs; color = inhibition % on SIK2.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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