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STK33

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UniProt Q9BYT3 · PDB · AlphaFold · Substrate: MBP · Clone: full length

Top inhibitors

#DrugInhibitionResidualKISSGini
1Bosutinib83.0%17.0%87.220.555
2Brigatinib79.8%20.2%82.960.513
3Sunitinib79.7%20.3%91.730.524
4Defactinib78.1%21.9%92.680.450
5Abemaciclib75.5%24.5%91.480.563
6Midostaurin74.7%25.3%78.640.500
7Pacritinib72.4%27.6%88.640.452
8Alectinib71.7%28.3%95.490.651
9Gilteritinib66.4%33.6%88.970.506
10Ceritinib66.4%33.6%95.440.618
11Netarsudil61.6%38.4%93.220.676
12Fedratinib49.4%50.6%96.210.576
13Osimertinib48.0%52.0%97.240.733
14Neratinib48.0%52.0%93.180.597
15Capivasertib46.9%53.1%96.480.644
16Palbociclib42.1%57.9%98.750.673
17Ponatinib40.1%59.9%78.230.534
18Fostamatinib37.8%62.2%96.740.613
19Nintedanib35.4%64.6%90.230.608
20Avapritinib33.0%67.0%97.730.644

Paralog block

No paralog group registered for this kinase.

EMT expression

  • Mesenchymal log2(TPM+1): 1.77
  • Epithelial log2(TPM+1): 1.26
  • Fold change: 0.50
  • Status: No significant change

Selectivity landscape vs inhibition on STK33

Each point is one of the 92 approved drugs; color = inhibition % on STK33.

3D structure

Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.

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