UniProt Q9UHD2 · PDB · AlphaFold · Substrate: MBP · Clone: full-length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Midostaurin | 87.1% | 12.9% | 78.64 | 0.500 |
| 2 | Pacritinib | 70.8% | 29.2% | 88.64 | 0.452 |
| 3 | Nintedanib | 67.1% | 32.9% | 90.23 | 0.608 |
| 4 | Fedratinib | 44.1% | 55.9% | 96.21 | 0.576 |
| 5 | Bosutinib | 43.8% | 56.2% | 87.22 | 0.555 |
| 6 | Sunitinib | 30.3% | 69.7% | 91.73 | 0.524 |
| 7 | Axitinib | 30.1% | 69.9% | 93.23 | 0.688 |
| 8 | Defactinib | 28.1% | 71.9% | 92.68 | 0.450 |
| 9 | Deucravacitinib | 26.0% | 74.0% | 98.99 | 0.718 |
| 10 | Abemaciclib | 21.7% | 78.3% | 91.48 | 0.563 |
| 11 | Canertinib | 21.6% | 78.4% | 96.49 | 0.671 |
| 12 | Entrectinib | 20.5% | 79.5% | 93.69 | 0.671 |
| 13 | Fostamatinib | 18.3% | 81.7% | 96.74 | 0.613 |
| 14 | Umbralisib | 14.9% | 85.1% | 98.74 | 0.670 |
| 15 | Gilteritinib | 14.1% | 85.9% | 88.97 | 0.506 |
| 16 | Pexidartinib | 13.8% | 86.2% | 99.49 | 0.631 |
| 17 | Ribociclib | 12.2% | 87.8% | 99.25 | 0.729 |
| 18 | Selpercatinib | 11.6% | 88.4% | 96.72 | 0.635 |
| 19 | Asciminib | 11.6% | 88.4% | 100.00 | 0.602 |
| 20 | Imatinib | 11.1% | 88.9% | 99.00 | 0.718 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 4.74
- Epithelial log2(TPM+1): 4.75
- Fold change: -0.01
- Status: No significant change
Selectivity landscape vs inhibition on TBK1
Each point is one of the 92 approved drugs; color = inhibition % on TBK1.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
Annotations
Sign in to read and post annotations.
Loading…