UniProt P42680 · PDB · AlphaFold · Substrate: pEY + Mn · Clone: full length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Ibrutinib | 98.7% | 1.3% | 94.74 | 0.723 |
| 2 | Dasatinib | 98.5% | 1.5% | 87.97 | 0.699 |
| 3 | Zanubrutinib | 95.8% | 4.2% | 98.24 | 0.788 |
| 4 | Bosutinib | 94.2% | 5.8% | 87.22 | 0.555 |
| 5 | Mobocertinib | 91.6% | 8.4% | 97.22 | 0.757 |
| 6 | Repotrectinib | 89.6% | 10.4% | 84.21 | 0.608 |
| 7 | Acalabrutinib | 87.4% | 12.6% | 99.50 | 0.670 |
| 8 | Canertinib | 78.9% | 21.1% | 96.49 | 0.671 |
| 9 | Fostamatinib | 75.1% | 24.9% | 96.74 | 0.613 |
| 10 | Osimertinib | 74.6% | 25.4% | 97.24 | 0.733 |
| 11 | Entrectinib | 74.0% | 26.0% | 93.69 | 0.671 |
| 12 | Remibrutinib | 71.9% | 28.1% | 99.50 | 0.721 |
| 13 | Pacritinib | 71.8% | 28.3% | 88.64 | 0.452 |
| 14 | Nintedanib | 68.3% | 31.7% | 90.23 | 0.608 |
| 15 | Pirtobrutinib | 66.9% | 33.1% | 99.49 | 0.656 |
| 16 | Neratinib | 65.9% | 34.1% | 93.18 | 0.597 |
| 17 | Brigatinib | 52.8% | 47.2% | 82.96 | 0.513 |
| 18 | Pralsetinib | 51.8% | 48.2% | 93.43 | 0.643 |
| 19 | Gilteritinib | 31.7% | 68.3% | 88.97 | 0.506 |
| 20 | Selpercatinib | 30.9% | 69.1% | 96.72 | 0.635 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 0.86
- Epithelial log2(TPM+1): 1.39
- Fold change: -0.53
- Status: No significant change
Selectivity landscape vs inhibition on TEC
Each point is one of the 92 approved drugs; color = inhibition % on TEC.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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