TNK2(ACK1)
Sign in to save this workspaceUniProt Q07912 · PDB · AlphaFold · Substrate: Lyntide 2+Mn · Clone: aa 110-476
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Bosutinib | 100.0% | 0.0% | 87.22 | 0.555 |
| 2 | Lorlatinib | 99.3% | 0.7% | 97.24 | 0.694 |
| 3 | Repotrectinib | 99.0% | 1.0% | 84.21 | 0.608 |
| 4 | Brigatinib | 98.0% | 2.0% | 82.96 | 0.513 |
| 5 | Dasatinib | 97.8% | 2.3% | 87.97 | 0.699 |
| 6 | Mobocertinib | 97.4% | 2.6% | 97.22 | 0.757 |
| 7 | Entrectinib | 97.3% | 2.7% | 93.69 | 0.671 |
| 8 | Ceritinib | 97.2% | 2.8% | 95.44 | 0.618 |
| 9 | Midostaurin | 96.9% | 3.1% | 78.64 | 0.500 |
| 10 | Neratinib | 95.2% | 4.8% | 93.18 | 0.597 |
| 11 | Ponatinib | 94.9% | 5.1% | 78.23 | 0.534 |
| 12 | Pacritinib | 94.5% | 5.5% | 88.64 | 0.452 |
| 13 | Fedratinib | 93.4% | 6.6% | 96.21 | 0.576 |
| 14 | Osimertinib | 92.6% | 7.4% | 97.24 | 0.733 |
| 15 | Alectinib | 89.2% | 10.8% | 95.49 | 0.651 |
| 16 | Gilteritinib | 87.8% | 12.2% | 88.97 | 0.506 |
| 17 | Vemurafenib | 85.6% | 14.4% | 96.49 | 0.598 |
| 18 | Pralsetinib | 80.5% | 19.5% | 93.43 | 0.643 |
| 19 | Baricitinib | 79.5% | 20.5% | 97.99 | 0.616 |
| 20 | Ruxolitinib | 78.5% | 21.5% | 98.25 | 0.592 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 3.79
- Epithelial log2(TPM+1): 4.34
- Fold change: -0.55
- Status: No significant change
Selectivity landscape vs inhibition on TNK2
Each point is one of the 92 approved drugs; color = inhibition % on TNK2.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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