Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · medullo-epn-umap@date-based

ERR2598336

fetal · fetal

041b9e6d-cc73-5946-bde4-5ba569eacfcf

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
fetal
cancer_type_detailed
—
subtype
fetal
cancer_type
fetal
subtype
fetal
sex
fetal
race
fetal
fetal_age_forebrain
22
umap1_2d
-2.288981146
umap2_2d
4.740176917
umap1_3d
1.106214094
umap2_3d
0.526497767
umap3_3d
0.18346899
dataset
fetal

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • KRAS_SIGNALING_DN+0.440
  • MYOGENESIS+0.400
  • PANCREAS_BETA_CELLS+0.400
  • COAGULATION+0.350
  • INFLAMMATORY_RESPONSE+0.340
  • INTERFERON_ALPHA_RESPONSE+0.310
  • ALLOGRAFT_REJECTION+0.290
  • KRAS_SIGNALING_UP+0.280
  • COMPLEMENT+0.270
  • APICAL_SURFACE+0.260

Top 10 suppressed

  • MYC_TARGETS_V1-0.620
  • E2F_TARGETS-0.550
  • MYC_TARGETS_V2-0.530
  • G2M_CHECKPOINT-0.510
  • DNA_REPAIR-0.470
  • PROTEIN_SECRETION-0.450
  • UNFOLDED_PROTEIN_RESPONSE-0.440
  • MITOTIC_SPINDLE-0.420
  • MTORC1_SIGNALING-0.360
  • OXIDATIVE_PHOSPHORYLATION-0.330

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

2 twins match this tumor's tissue · 8 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1MDT-AP-0746
medullo-epn-umap@date-based
MedMedulloblastoma0.955
2MDT-AP-1215
medullo-epn-umap@date-based
MedMedulloblastoma0.941
3SRR1366961
brain-umap@2
GTEX—0.937
4SRR1335707
brain-umap@2
GTEX—0.934
5ERR2598288
medullo-epn-umap@date-based
fetalfetal0.934
6SRR601006
brain-umap@2
GTEX—0.932
7SRR1375203
brain-umap@2
GTEX—0.932
8SRR8943034
bladder-landscape@3
——0.931
9SRR607478
brain-umap@2
GTEX—0.928
10SRR1397906
brain-umap@2
GTEX—0.927

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 26 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
KRAS_SIGNALING_DN0.440Remibrutinib— uncovered
MYOGENESIS0.400Inavolisib— uncovered
PANCREAS_BETA_CELLS0.400Cobimetinib— uncovered
COAGULATION0.350Binimetinib— uncovered
INFLAMMATORY_RESPONSE0.340Idelalisib— uncovered
INTERFERON_ALPHA_RESPONSE0.310Inavolisib— uncovered
ALLOGRAFT_REJECTION0.290Idelalisib— uncovered
KRAS_SIGNALING_UP0.280Inavolisib— uncovered
COMPLEMENT0.270Inavolisib— uncovered
APICAL_SURFACE0.260Temsirolimus— uncovered
ESTROGEN_RESPONSE_LATE0.260Idelalisib— uncovered
APICAL_JUNCTION0.240Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.210Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.190Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.180Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.180Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.180Idelalisib— uncovered
ANGIOGENESIS0.160Remibrutinib— uncovered
SPERMATOGENESIS0.150Inavolisib— uncovered
IL2_STAT5_SIGNALING0.140Idelalisib— uncovered