Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

ERR2598288

fetal · fetal

3fb4ecd3-a8fa-52cc-bc2c-5daf24265ab9

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
fetal
cancer_type_detailed
subtype
fetal
cancer_type
fetal
subtype
fetal
sex
fetal
race
fetal
fetal_age_forebrain
21
umap1_2d
-2.136342739
umap2_2d
5.115914046
umap1_3d
1.241576149
umap2_3d
0.554845511
umap3_3d
0.050455844
dataset
fetal

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

1 twin match this tumor's tissue · 9 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1ERR2598336
medullo-epn-umap@date-based
fetalfetal0.934
2SRR1366961
brain-umap@2
GTEX0.922
3SRR1473822
brain-umap@2
GTEX0.920
4SRR1455698
brain-umap@2
GTEX0.910
5SRR1472301
brain-umap@2
GTEX0.908
6SRR1310113
brain-umap@2
GTEX0.907
7SRR1431229
brain-umap@2
GTEX0.905
8SRR819946
brain-umap@2
GTEX0.903
9SRR1370240
brain-umap@2
GTEX0.903
10SRR1500998
brain-umap@2
GTEX0.903

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 24 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
SPERMATOGENESIS0.480Inavolisib— uncovered
KRAS_SIGNALING_DN0.420Remibrutinib— uncovered
COAGULATION0.370Binimetinib— uncovered
PANCREAS_BETA_CELLS0.370Cobimetinib— uncovered
INFLAMMATORY_RESPONSE0.310Idelalisib— uncovered
MYOGENESIS0.280Inavolisib— uncovered
ALLOGRAFT_REJECTION0.270Idelalisib— uncovered
COMPLEMENT0.240Inavolisib— uncovered
KRAS_SIGNALING_UP0.240Inavolisib— uncovered
BILE_ACID_METABOLISM0.230Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.230Idelalisib— uncovered
XENOBIOTIC_METABOLISM0.220Inavolisib— uncovered
APICAL_SURFACE0.200Temsirolimus— uncovered
IL6_JAK_STAT3_SIGNALING0.200Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.180Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.170Inavolisib— uncovered
FATTY_ACID_METABOLISM0.150Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.130Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.130Idelalisib— uncovered
ESTROGEN_RESPONSE_EARLY0.120Inavolisib— uncovered