Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SJBT031026_D1.RNA-Seq

EPN · Spinal EPN

052a9106-7f60-50f6-9797-7e7a0354d80f

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
EPN
cancer_type_detailed
subtype
Spinal EPN
cancer_type
EPN
subtype
Spinal EPN
age_years
16.28
e1_e2
E1
umap1_2d
-1.422364397
umap2_2d
2.482913365
umap1_3d
-0.234170687
umap2_3d
0.161313158
umap3_3d
-0.772847918
dataset
EPN-StJude

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

1 twin match this tumor's tissue · 9 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1BS_Y3G1X98S
brain-umap@2
Meningioma0.857
2BS_53CTGDQG
brain-umap@2
Meningioma0.846
3SJBT031026_D3.RNA-Seq
medullo-epn-umap@date-based
EPNSpinal EPN0.844
4BS_49VCQD19
brain-umap@2
Neurofibroma0.842
5BS_9HA238XS
brain-umap@2
Neurofibroma0.835
6BS_Q2T9ZRM0
brain-umap@2
Meningioma0.835
7BS_NDRDM2A9
brain-umap@2
Neurofibroma0.834
8BS_RQSKD7PN
brain-umap@2
MPNST0.832
9BS_7H4RFCW9
brain-umap@2
low-grade glioma0.831
10BS_THSPSG2Z
brain-umap@2
Meningioma0.828

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 30 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
ALLOGRAFT_REJECTION0.490Idelalisib— uncovered
INFLAMMATORY_RESPONSE0.460Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.450Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.410Idelalisib— uncovered
IL2_STAT5_SIGNALING0.360Idelalisib— uncovered
COMPLEMENT0.350Inavolisib— uncovered
ANDROGEN_RESPONSE0.320Inavolisib— uncovered
TGF_BETA_SIGNALING0.320Inavolisib— uncovered
UV_RESPONSE_DN0.320Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.310Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.310Inavolisib— uncovered
ANGIOGENESIS0.260Remibrutinib— uncovered
APICAL_SURFACE0.260Temsirolimus— uncovered
NOTCH_SIGNALING0.260Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.250Inavolisib— uncovered
KRAS_SIGNALING_UP0.250Inavolisib— uncovered
APOPTOSIS0.220Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.200Inavolisib— uncovered
COAGULATION0.180Binimetinib— uncovered
PROTEIN_SECRETION0.180Remibrutinib— uncovered