Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

BS_53CTGDQG

Meningioma

2ad0ac78-e708-5ab1-a580-ab9d020dfbd8

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
Meningioma
cancer_type_detailed
subtype
cancer_type
Meningioma
overall_survival_months
194.94086727989486
age_years
14.879
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • INTERFERON_ALPHA_RESPONSE+0.470
  • ALLOGRAFT_REJECTION+0.428
  • INTERFERON_GAMMA_RESPONSE+0.426
  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.409
  • IL6_JAK_STAT3_SIGNALING+0.406
  • APOPTOSIS+0.378
  • COAGULATION+0.339
  • INFLAMMATORY_RESPONSE+0.333
  • PROTEIN_SECRETION+0.330
  • UV_RESPONSE_DN+0.302

Top 10 suppressed

  • G2M_CHECKPOINT-0.320
  • E2F_TARGETS-0.312
  • HEDGEHOG_SIGNALING-0.264
  • MYC_TARGETS_V2-0.217
  • MITOTIC_SPINDLE-0.200
  • SPERMATOGENESIS-0.192
  • PANCREAS_BETA_CELLS-0.170
  • DNA_REPAIR-0.109
  • MYC_TARGETS_V1-0.103
  • UV_RESPONSE_UP-0.090

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

5 twins match this tumor's tissue · 5 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1BS_Y3G1X98S
brain-umap@2
Meningioma0.915
2BS_10APZRVT
brain-umap@2
Meningioma0.905
3BS_KF0ZXDER
brain-umap@2
Meningioma0.896
4BS_THSPSG2Z
brain-umap@2
Meningioma0.890
5BS_VJAC9H58
brain-umap@2
Schwannoma0.886
6MDT-AP-2021
medullo-epn-umap@date-based
MedMedulloblastoma0.885
7BS_JGPR9SR2
brain-umap@2
Meningioma0.881
8BS_Q79NP5YY
brain-umap@2
pilocytic astrocytoma0.879
9BS_F8N6CFQE
brain-umap@2
low-grade glioma0.877
10BS_014EVM2D
brain-umap@2
low-grade glioma0.876

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 35 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.470Inavolisib— uncovered
ALLOGRAFT_REJECTION0.428Idelalisib— uncovered
INTERFERON_GAMMA_RESPONSE0.426Idelalisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.409Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.406Inavolisib— uncovered
APOPTOSIS0.378Idelalisib— uncovered
COAGULATION0.339Binimetinib— uncovered
INFLAMMATORY_RESPONSE0.333Idelalisib— uncovered
PROTEIN_SECRETION0.330Remibrutinib— uncovered
UV_RESPONSE_DN0.302Inavolisib— uncovered
APICAL_SURFACE0.293Temsirolimus— uncovered
PI3K_AKT_MTOR_SIGNALING0.267Inavolisib— uncovered
IL2_STAT5_SIGNALING0.263Idelalisib— uncovered
ANGIOGENESIS0.238Remibrutinib— uncovered
XENOBIOTIC_METABOLISM0.228Inavolisib— uncovered
TGF_BETA_SIGNALING0.223Inavolisib— uncovered
COMPLEMENT0.213Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.210Inavolisib— uncovered
ANDROGEN_RESPONSE0.209Inavolisib— uncovered
ADIPOGENESIS0.199Inavolisib— uncovered