Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SRR5088910

05d7bd56-6b35-5251-9180-325064f8a1c9

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR5088860
melanoma-umap@29
0.932
2TCGA-OR-A5JO-01
acc-tcga-pancan-2018@2018
Adrenocortical CarcinomaAdrenocortical Carcinoma, Usual Type0.930
3SRR22247245
lung-landscapes@6
cohortMD20.923
4SRR5088928
melanoma-umap@29
0.919
5SRR8526722
lung-landscapes@6
cohortMD20.916
66bf9821d-da67-470f-9650-69d05b056166
melanoma-umap@29
0.906
7SRR5088825
melanoma-umap@29
0.905
8e5b29c06-2ed0-4913-bf24-5bfde047defc
melanoma-umap@29
0.904
92d12ea90-c4f4-4aca-b353-360057b446e2
melanoma-umap@29
0.901
10SRR10842349
melanoma-umap@29
0.901

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 26 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
ALLOGRAFT_REJECTION0.600Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.600Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.600Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.600Idelalisib— uncovered
COMPLEMENT0.500Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.500Idelalisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.400Inavolisib— uncovered
APICAL_JUNCTION0.300Inavolisib— uncovered
APOPTOSIS0.300Idelalisib— uncovered
IL2_STAT5_SIGNALING0.300Idelalisib— uncovered
KRAS_SIGNALING_UP0.300Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.300Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.300Inavolisib— uncovered
COAGULATION0.200Binimetinib— uncovered
HEME_METABOLISM0.200Temsirolimus— uncovered
MYOGENESIS0.200Inavolisib— uncovered
P53_PATHWAY0.200Idelalisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.200Inavolisib— uncovered
UV_RESPONSE_DN0.200Inavolisib— uncovered
ANGIOGENESIS0.100Remibrutinib— uncovered